{"id":20328,"date":"2023-08-07T23:56:00","date_gmt":"2023-08-07T15:56:00","guid":{"rendered":"https:\/\/www.granitefirm.com\/blog\/us\/?p=20328"},"modified":"2025-11-07T11:29:08","modified_gmt":"2025-11-07T03:29:08","slug":"weight-loss-is-golden-goose","status":"publish","type":"post","link":"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/","title":{"rendered":"Weight loss is the future golden goose of the drug market"},"content":{"rendered":"\n<p><strong>Reminder<\/strong>: It is strongly recommended that you read my other highly relevant post after reading this article &#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/03\/30\/novo-nordisks-new-diabetes-drug-semaglutide-and-incretin-found-to-have-surprising-weight-loss-effects\/\">Novo Nordisk&#8217;s new diabetes drug Semaglutide,Ozempic,Wegovy and Mounjaro found to have surprising weight-loss effects<\/a>&#8220;<\/p>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #ffffff;color:#ffffff\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #ffffff;color:#ffffff\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#The_potential_weight_loss_opportunities\" >The potential weight loss opportunities<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#How_many_people_need_to_lose_weight\" >How many people need to lose weight?<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Worldwide\" >Worldwide<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#US\" >U.S.<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#China\" >China<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Europe\" >Europe<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Taiwan\" >Taiwan<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#How_big_is_the_weight_loss_market\" >How big is the weight loss market<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#When_do_you_need_to_lose_weight\" >When do you need to lose weight?<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Weight-loss_drugs_approved\" >Weight-loss drugs approved<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#FDA\" >FDA<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Taiwan_Ministry_of_Health_and_Welfare\" >Taiwan Ministry of Health and Welfare<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#How_many_well-known_weight-loss_drugs_containing_enterocrin_are_there\" >How many well-known weight-loss drugs containing enterocrin are there?<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Saxenda\" >Saxenda<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Trulicity\" >Trulicity<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Efinopegdutide\" >Efinopegdutide<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Semaglutide\" >Semaglutide<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Simple_bio\" >Simple bio<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Three_FDA-approved_semaglutide_drugs\" >Three FDA-approved semaglutide drugs<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Ozempic\" >Ozempic<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Wegovy\" >Wegovy<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Danuglipron\" >Danuglipron<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Monzaro_is_the_superstar_of_the_future\" >Monzaro is the superstar of the future<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#The_future_Eli_Lilly_bets\" >The future Eli Lilly bets<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Amazing_weight_loss\" >Amazing weight loss<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Effects_Similar_to_Bariatric_Surgery\" >Effects Similar to Bariatric Surgery<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Differences_among_weight-loss_drugs\" >Differences among weight-loss drugs<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-28\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Oral_administration_can_expand_the_market\" >Oral administration can expand the market<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-29\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Advantages_of_the_oral_route\" >Advantages of the oral route<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-30\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Well-known_weight_loss_oral_drugs\" >Well-known weight loss oral drugs<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-31\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Side_effects\" >Side effects<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-32\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Food_industry_has_taken_a_hit\" >Food industry has taken a hit<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-33\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Celebrity_push\" >Celebrity push<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-34\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Market_value_of_related_companies_has_skyrocketed\" >Market value of related companies has skyrocketed<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-35\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Related_drugs_are_in_short_supply\" >Related drugs are in short supply<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-36\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#New_indications_discovered\" >New indications discovered<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-37\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#The_amazing_GLP-1\" >The amazing GLP-1<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-38\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Shanxianda_make_people_smarter\" >Shanxianda make people smarter<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-39\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Ozempic_helps_quit_addiction\" >Ozempic helps quit addiction<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-40\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Risk\" >Risk<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-41\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Potential_self-harm_side_effects\" >Potential self-harm side effects<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-42\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Regain_lost_weight_within_a_year_of_stopping_the_drug\" >Regain lost weight within a year of stopping the drug<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-43\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Regulatory_advice\" >Regulatory advice<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-44\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Obvious_side_effects\" >Obvious side effects<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-45\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Potential_Risks\" >Potential Risks<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-46\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/#Relative_articles\" >Relative articles<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"The_potential_weight_loss_opportunities\"><\/span>The potential weight loss opportunities<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_many_people_need_to_lose_weight\"><\/span>How many people need to lose weight?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Worldwide\"><\/span>Worldwide<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>According to <a href=\"https:\/\/www.ucl.ac.uk\/news\/2018\/may\/almost-1-4-people-worldwide-be-obese-2045\" target=\"_blank\" rel=\"noreferrer noopener\">statistics from the 2018 European Obesity Conference<\/a>: In 2017, the global obese population rate was 14%, and 9% had type 2 diabetes. By 2045, the two data will become 22% and 12%; 39% in 2045 to 55%. <\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"US\"><\/span>U.S.<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>According to a 2023 study in the Journal of the American Medical Association, between 2009 and 2020, the prevalence of diabetes in American adults rose from 3% to 4%, and the obesity rate rose from 32.7% to 40.9%. Healthcare spending reached $173 billion. <\/p>\n\n\n\n<p>According to the National Institutes of Health, more than two-fifths of American adults are obese, and about one in 10 is severely obese.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"China\"><\/span>China<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>The National Health and Medical Commission of China pointed out in 2021 that the overweight rate of Chinese adult residents exceeds 50%, and 16.4% of them are obese. <\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Europe\"><\/span>Europe<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>In the WHO European Region, <a href=\"https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/353747\/9789289057738-eng.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">overweight and obesity affect nearly 60% of adults and almost one third of children<\/a> (29% of boys and 27% of girls).<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Taiwan\"><\/span>Taiwan<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>According to statistics from the National Health Service of the Ministry of Health and Welfare, the prevalence rate of overweight and obesity among adults in Taiwan is 43%, with 48.9% of males and 38.3% of females.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_big_is_the_weight_loss_market\"><\/span>How big is the weight loss market<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Baron&#8217;s Weekly reported that incretin has unprecedented weight loss effects. Even safely lose a fifth of your body weight, and it is expected to become the world&#8217;s best-selling drug. It is estimated that the annual sales of incretin will exceed US$50 billion from 2030, and the market will be divided between Novo Nordisk and Eli Lilly. <\/p>\n\n\n\n<p>The current market size for weight loss is US$1 billion, and it can easily exceed US$10 billion in the next few years. Including Eli Lilly (ticker: LLY), Novo Nordisk (ticker: NVO), Amgen (ticker: AMGN), Pfizer (ticker: PFE), Regeneron (ticker: REGN ), Merck (ticker: MRK), Roche (ticker: RHHBY), GSK (ticker: GSK), Rhythm Pharmaceuticals (ticker: RYTM ) and other global pharmaceutical giants have joined the battlefield, and have or are developing related products, aiming at this blue ocean market that is expected to reach an annual revenue of US$50 billion within ten years.<\/p>\n\n\n\n<p>Goldman Sachs predicts that the weight-loss drug market is expected to reach US$100 billion. By 2030, the global anti-obesity drug market may grow to approximately US$100 billion (annual sales at the beginning of 2023 are approximately US$6 billion). This projection is based on approximately 15 million U.S. adults receiving weight loss medications for chronic weight loss management in 2030, and approximately 105 million U.S. adults being obese or overweight. Analysts exclude people with diabetes from obesity forecasts.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"When_do_you_need_to_lose_weight\"><\/span>When do you need to lose weight?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>According to the regulations of the US FDA, the above weight-loss drugs can only be used if the following conditions are met:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>BMI greater than 30<\/li>\n\n\n\n<li>BMI greater than or equal to 27 and related diseases<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Weight-loss_drugs_approved\"><\/span>Weight-loss drugs approved<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"FDA\"><\/span>FDA<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Six diet pills have been approved by the U.S. Food and Drug Administration (FDA) for long-term use:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Brand name<\/td><td>Generic name<\/td><td>Pharmaceutical  company<\/td><td>Available year<\/td><td>Weight loss in 1 year<\/td><td>Mechanism<\/td><\/tr><tr><td>Xenical<\/td><td>Orlistat<\/td><td>Roche, GSK<\/td><td>2007<\/td><td>11.0%<\/td><td>\u8102\u80aa\u5206\u89e3\u9175\u7d20\u6291\u5236\u5291<\/td><\/tr><tr><td>Qsymia<\/td><td>Phentermine-Topiramate<\/td><td>Vivus<\/td><td>2012<\/td><td>9.3%<\/td><td>\u52a0\u5f37\u53bb\u7532\u814e\u4e0a\u817a\u7d20\u548c\u591a\u5df4\u80fa\u7684\u795e\u7d93\u50b3\u905e\u4f86\u7522\u751f\u6291\u5236\u98df\u617e<\/td><\/tr><tr><td>Contrave<\/td><td>Bupropion-Naltrexone<\/td><td>Nalpropion<\/td><td>2014<\/td><td>5.2%<\/td><td>\u9078\u64c7\u6027\u53bb\u7532\u814e\u4e0a\u817a\u7d20\u548c\u591a\u5df4\u80fa\u518d\u651d\u53d6\u6291\u88fd\u5291<\/td><\/tr><tr><td>Saxenda<\/td><td>Liraglutide<\/td><td>Novo Nordisk<\/td><td>2014<\/td><td>5.6%<\/td><td>GLP-1\u53d7\u9ad4\u4e0a\u7684\u8178\u6ccc\u7d20\u85e5\u7269<\/td><\/tr><tr><td>Imcivree<\/td><td>Setmelanotide<\/td><td>Rhythm<br>Pharmaceuticals<\/td><td>2020<\/td><td>10.0%<\/td><td>MC4R\u6fc0\u52d5\u5291<\/td><\/tr><tr><td>Wegovy<\/td><td>Semaglutide<\/td><td>Novo Nordisk<\/td><td>2021<\/td><td>15.0%<\/td><td>GLP-1\u53d7\u9ad4\u6fc0\u52d5\u5291<\/td><\/tr><\/tbody><\/table><figcaption class=\"wp-element-caption\">Table 1: Six Weight Loss Drugs Approved by the FDA<\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Taiwan_Ministry_of_Health_and_Welfare\"><\/span>Taiwan Ministry of Health and Welfare<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>At present, there are only two legal weight-loss drugs approved in Taiwan:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Xenical<\/li>\n\n\n\n<li>Belviq<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_many_well-known_weight-loss_drugs_containing_enterocrin_are_there\"><\/span>How many well-known weight-loss drugs containing enterocrin are there?<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Saxenda\"><\/span>Saxenda<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>The main ingredient in Novo Nordisk&#8217;s Saxenda weight loss daily injection pen is Liraglutide, which is improved from Victoza, a prescription drug that was originally prescribed for patients with type 2 diabetes. For weight loss indications in adults, it is an incretin drug that acts on the GLP-1 receptor. Novo Nordisk&#8217;s 1-year clinical results indicated that about 60% of the subjects lost less than 5% of their body weight, and 34% of them lost more than 10%.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Trulicity\"><\/span>Trulicity<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Eli Lilly&#8217;s Trulicity is a once-a-week pen injection that contains dulaglutide, a GLP-1 receptor enhancer, and belongs to the enterocrin type of blood sugar control drug.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Efinopegdutide\"><\/span>Efinopegdutide<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Merck&#8217;s (tickere: MRK) drug Efinopegdutide, which reduces fatty liver, has shown a better effect than the FDA-approved drug semaglutide in the second phase of clinical trials, and can reduce fatty liver by about 70%. Body weight is reduced by about 8%.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Semaglutide\"><\/span>Semaglutide<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Simple_bio\"><\/span>Simple bio<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Semaglutide was developed by Novo Nordisk in 2012. It is a GLP-1 receptor agonist. The trade names on the market are Ozempic, Wegovy and Rybelsus. The difference among these three is the difference in dosage.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Three_FDA-approved_semaglutide_drugs\"><\/span>Three FDA-approved semaglutide drugs<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>At present, Novo Nordisk has three semaglutide drugs approved by the FDA, and the brand names are Ozempic, Wegovy and Rybelsus (oral dosage). Among the three drugs, only Wegovy (2.4mg, once a week) has been approved by the FDA for weight loss indications for chronic chronic weight management.<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ozempic\"><\/span>Ozempic<span class=\"ez-toc-section-end\"><\/span><\/h5>\n\n\n\n<p>In December 2017, Ozempic was approved by the FDA for the treatment of type 2 diabetes. It can stimulate the body&#8217;s insulin production. It is administered once a week, reduce appetite and help people lose weight significantly. After 56 weeks of testing, patients who received low-dose semaglutide lost an average of 4.3 kg in weight, and those who received high-dose semaglutide lost 6.1 kg.<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Wegovy\"><\/span>Wegovy<span class=\"ez-toc-section-end\"><\/span><\/h5>\n\n\n\n<p>Novo Nordisk will be approved by the FDA in 2022 and marketed under the brand name Wegovy. It is an injectable weight loss drug that specializes in weight loss. According to the Novo Nordisk study, Wegovy participants lost an average of 15% of their body weight, about 34 pounds, and the weight loss remained stable after 14 months.<\/p>\n\n\n\n<p>On August 8, 2023, Novo Nordisk announced that Wegovy has been found to have a potential role in reducing the risk of serious cardiovascular diseases. The latest clinical results allow Novo Nordisk to apply for a new indication for Wegovy, which will increase the usage rate of Wegovy by about a quarter and bring more revenue to the company. On that day, all weight-loss-related stocks in the U.S. stock market rose by at least ten percent, and the stock price of Novo Nordisk, which is listed in the U.S., soared by more than 16%.<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Danuglipron\"><\/span>Danuglipron<span class=\"ez-toc-section-end\"><\/span><\/h5>\n\n\n\n<p>Pfizer expects to finalize Danuglipron&#8217;s phase III clinical trial plan by the end of 2023. Danuglipron and Novo Nordisk&#8217;s blockbuster weight-loss injections Ozempic and Wegovy are drugs for the glucagon-like peptide-1 (GLP-1) hormone. Pfizer Chief Executive Albert Bourla said the weight-loss drug could eventually generate $10 billion in annual revenue for the company.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Monzaro_is_the_superstar_of_the_future\"><\/span>Monzaro is the superstar of the future<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"The_future_Eli_Lilly_bets\"><\/span>The future Eli Lilly bets<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Eli Lilly&#8217;s incretin drug is called tirzepatide and is marketed as Mounjaro. Approved by the FDA in 2022 for the treatment of type 2 diabetes in adults, it is a dual incretin (GLP-1 and GIP) agonist, the first new type of diabetes drug in ten years, administered once a week by subcutaneous injection , will become a heavyweight competitor of Novo Nordisk.<\/p>\n\n\n\n<p>Benefited from August 8, 2023, Novo Nordisk announced that the company&#8217;s weight-loss drug Wegovy has potential new indications in the field of reducing the risk of serious cardiovascular diseases, and also has GLP-1 receptor agonist drugs Eli Lilly shares also rose sharply. In addition, on the same day, the company announced the results of the second quarter financial report, the most important of which was driven by the weight-loss drug Monzaro. The new product contributed US$1 billion in revenue in the second quarter, and the closing stock price soared more than 100 million dollars in one day. 14%, the market value surpassed Johnson &amp; Johnson to become the most valuable listed pharmaceutical company in the world again.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Amazing_weight_loss\"><\/span>Amazing weight loss<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Although tirzepatide is not yet approved for weight loss, the new drug has catapulted Lilly into one of Wall Street&#8217;s favorites. Lilly announced on April 28, 2022 that subjects could lose an average of 15% of their body weight if they took a low dose; if they took a high dose, they could lose an average of 22.5% of their body weight. The results could speed up the drug&#8217;s FDA approval.<\/p>\n\n\n\n<p>According to the latest interim clinical trial results released on 6\/26\/2023, the second phase of the trial followed 338 obese or overweight adults. The subjects took Eli Lilly&#8217;s experimental drug tirzepatide weekly to help patients lose weight for nearly a year. They lost up to 24% of their body weight, the highest rate of weight loss ever seen in the field of obesity treatment. Even after only taking it for 24 weeks, the average weight loss was 17.5%.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Effects_Similar_to_Bariatric_Surgery\"><\/span>Effects Similar to Bariatric Surgery<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Lilly said, &#8220;We think this is a major breakthrough in obesity treatment; it is the only drug that can lose an average of more than 20% of body weight in phase III clinical trials. The effect is similar to bariatric surgery, without invasive procedures and There is no risk of surgical complications. In phase III clinical trials, an average of 20% of body weight was lost.\u201d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Differences_among_weight-loss_drugs\"><\/span>Differences among weight-loss drugs <span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Like Wegovy and Mounjaro, Eli Lilly&#8217;s retatrutide is injected once a week and changes the way patients eat by mimicking certain hormones in the gut, resulting in decreased appetite. <\/p>\n\n\n\n<p>But Wegovy mimics only one hunger-regulating hormone called GLP-1, while Mounjaro mimics both GLP-1 and another hormone called GIP. Retatutide mimics three different hunger-regulating hormones: GLP-1, GIP, and glucagon, which may have a greater impact on a person&#8217;s appetite and satisfaction with food.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Oral_administration_can_expand_the_market\"><\/span>Oral administration can expand the market<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Advantages_of_the_oral_route\"><\/span>Advantages of the oral route<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>BMO Capital Markets analyst Evan David Seigerman estimates that weight-loss drugs in pill form may account for about 15% of the total market, and he predicts global annual sales will reach 100 billion yuan in the next few years.<\/p>\n\n\n\n<p>Physicians and analysts say weight-loss drugs in pill form are unlikely to outperform current weekly injections for weight loss, given the chemical composition, and some pills may be even worse, and some are less effective than daily pills, physicians and analysts say. Patients may prefer the convenience of a weekly injection.<\/p>\n\n\n\n<p>However, experts also pointed out that if the price of weight-loss pills is lower, it may attract some patients.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Well-known_weight_loss_oral_drugs\"><\/span>Well-known weight loss oral drugs<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>According to the mid-term clinical trial results released by Eli Lilly on 6\/23\/2023, overweight or obese patients who took Orforglipron once a day lost 14.7% of their body weight after 36 weeks. Lilly said that the drug trial met its initial goals.<\/p>\n\n\n\n<p>Doctors usually prefer a once-daily pill like Orforglipron to Danuglipron twice a day. Based on convenience, tolerability, and magnitude of weight loss, Orforglipron may be a better choice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Side_effects\"><\/span>Side effects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Food_industry_has_taken_a_hit\"><\/span>Food industry has taken a hit<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>The popularity of new weight-loss drugs from Novo Nordisk and Eli Lilly in the United States has begun to have an impact on the traditional food and beverage industry. On October 5, 2023, Coca-Cola and Pepsi, the two major beverage giants in the United States, plunged 4.83% and 5.22% respectively, with their market values \u200b\u200bevaporating by US$11.5 billion and US$12.13 billion in one trading day. <\/p>\n\n\n\n<p>Prior to this, Walmart also issued a warning that consumers taking new diet pills from Novo Nordisk and Eli Lilly and Company, which have caused major changes in the U.S. food industry, have reduced shopping demand.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Celebrity_push\"><\/span>Celebrity push<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>In Hollywood, tech circles and celebrity circles, weight loss drugs have become a major talking point when talking about weight loss and thinning. Tesla CEO Musk, who was previously ridiculed by netizens for being too fat and needing to lose weight, tweeted in October 2022 that he lost 9 kilograms in one month. The secret is regular fasting and using Wegovy.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Market_value_of_related_companies_has_skyrocketed\"><\/span>Market value of related companies has skyrocketed<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>After Wegovy was approved for listing in 2022, the market demand was strong, and Novo Nordisk&#8217;s stock price rose by 50% in the following year, making Novo Nordisk&#8217;s P\/E 70% higher than its peers. Also because of incretin, the current stock price of Eli Lilly is about US$442, and the price-to-earnings ratio is twice that of its peers. In the past year, the market value of these two companies has rapidly squeezed into the top five listed pharmaceutical companies in the world.<\/p>\n\n\n\n<p><strong>Note<\/strong>: Inspired by Eli Lilly&#8217;s announcement of its second-quarter financial report on August 8, 2023, the performance of new drugs exceeded expectations, its stock price soared by 14%, and its market value surpassed Johnson &amp; Johnson to become the world&#8217;s most valuable listed pharmaceutical company again.<\/p>\n\n\n\n<p>On August 8, 2023, the market value of Novo Nordisk even approached that of LVMH (ticker: LVMHF), which has the largest market value in Europe.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>ticker<\/td><td>6\/2\/2023 share price<\/td><td>Stock performance in past 1 year<\/td><td>P\/E<\/td><td>Market value (US$ billion)<\/td><td>Dividend yield<\/td><\/tr><tr><td>ABBV<\/td><td>136.87<\/td><td>-6.59%<\/td><td>32.39<\/td><td>241.48<\/td><td>4.33%<\/td><\/tr><tr><td>AMGN<\/td><td>218.07<\/td><td>-11.15%<\/td><td>14.81<\/td><td>116.52<\/td><td>3.91%<\/td><\/tr><tr><td>GSK<\/td><td>34.28<\/td><td>-21.34%<\/td><td>3.79<\/td><td>70.49<\/td><td>4.07%<\/td><\/tr><tr><td>JNJ<\/td><td>156.97<\/td><td>-11.01%<\/td><td>32.84<\/td><td>407.92<\/td><td>3.03%<\/td><\/tr><tr><td>LLY<\/td><td>442.33<\/td><td>45.81%<\/td><td>70.22<\/td><td>419.89<\/td><td>1.02%<\/td><\/tr><tr><td>MRK<\/td><td>112.5<\/td><td>25.24%<\/td><td>21.96<\/td><td>285.51<\/td><td>2.60%<\/td><\/tr><tr><td>NVO<\/td><td>157.14<\/td><td>40.12%<\/td><td>40.65<\/td><td>270.65<\/td><td>1.12%<\/td><\/tr><tr><td>PFE<\/td><td>38.36<\/td><td>-27.98%<\/td><td>7.56<\/td><td>216.55<\/td><td>4.28%<\/td><\/tr><tr><td>REGN<\/td><td>739.95<\/td><td>21.50%<\/td><td>20.11<\/td><td>81.18<\/td><td>0.00%<\/td><\/tr><tr><td>RHHBY<\/td><td>40.21<\/td><td>-2.47%<\/td><td>19.02<\/td><td>262.94<\/td><td>0.00%<\/td><\/tr><tr><td>RYTM<\/td><td>17.34<\/td><td>413.61%<\/td><td>0<\/td><td>0.987<\/td><td>0.00%<\/td><\/tr><tr><td>PPH(VanEck Pharmaceutical ETF)<\/td><td>76.7<\/td><td>-1.86%<\/td><td>18.52<\/td><td>0.397<\/td><td>1.80%<\/td><\/tr><tr><td>S&amp;P 500<\/td><td>4,282.37<\/td><td>3.90%<\/td><td>18.52<\/td><td>35,002<\/td><td>1.80%<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Table 2: Stock price performance of companies related to weight loss (figures from Google Finance and Yahoo Finance)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Related_drugs_are_in_short_supply\"><\/span>Related drugs are in short supply<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Because it is regarded as a miracle drug for weight loss by people who are keen on weight loss, it will start to prevent diabetic patients who really need it from buying the drug in 2023. Diabetics in the U.S. say it takes them hours to find a nearby pharmacy that stocks the prescription drug; patients have even had to reduce their dose or switch to an alternative. <\/p>\n\n\n\n<p>Drug shortages make it harder for diabetics to keep blood sugar levels low, increasing the risk of complications such as kidney and blood vessel damage; the same is happening in Europe and China. The European Medicines Agency stated in March 2023 that related drugs will face a long-term shortage and will continue throughout 2023, and it is uncertain when it will improve; doctors are required to give priority to diabetes rather than weight loss.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"New_indications_discovered\"><\/span>New indications discovered<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"The_amazing_GLP-1\"><\/span>The amazing GLP-1<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>The most encouraging thing about the miraculous GLP-1 is that these new generation GLP-1 weight loss drugs have been found to have many new indications, which is exciting news for patients and investors. More than one clinical medical report pointed out that the effects of GLP-1 drugs are not limited to the field of weight loss, but are also effective in kidney disease, heart disease, sleep apnea, etc.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Shanxianda_make_people_smarter\"><\/span>Shanxianda make people smarter<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Obese people have abnormal metabolism and hormones, which will cause abnormal operation of brain neural circuits and reduce learning ability. Recently, German scientists discovered that a single dose of the weight-loss drug &#8220;Senfid&#8221; (the main ingredient is Liraglutide, note) can restore the insulin function and learning ability of obese people to normal. The findings were published in the journal Nature Metabolism in August.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ozempic_helps_quit_addiction\"><\/span>Ozempic helps quit addiction <span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Many users have found that diabetes drugs such as Ozempic not only help them lose weight, but also help them overcome overeating or alcohol or smoking addiction. So, could these diabetes medications serve as an alternative to withdrawal treatment for addictive behaviors? What are their active ingredients? How will it affect the brain? Can the effect last? Daniela Hernandez of The Wall Street Journal explains the above questions by combining scientific principles and experimental findings.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Risk\"><\/span>Risk<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Potential_self-harm_side_effects\"><\/span>Potential self-harm side effects <span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Europe&#8217;s drug safety regulator is reviewing Ozempic after reports of suicidal thoughts linked to the popular weight-loss drug and another drug in its class. The European Medicines Agency said on July 10, 2023 that it was assessing the safety risks of patients taking this type of drug produced by Novo Nordisk after learning that three users of the drug reported self-harm or suicidal thoughts.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Regain_lost_weight_within_a_year_of_stopping_the_drug\"><\/span>Regain lost weight within a year of stopping the drug<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Novo Nordisk clinical trials showed that patients who stopped taking the drug regained most of the lost weight within a year. In March this year, Novo Nordisk stated at a health summit: &#8220;The available data show that most people regain most of their body weight within five years of stopping Wegovy and about 50% of their weight after two to three years. weight.&#8221;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Regulatory_advice\"><\/span>Regulatory advice<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>GLP-1 drugs have recently been hailed by the market as a &#8220;magic drug for weight loss&#8221;, but the European Medicines Agency (EMA) has recently poured cold water on it. In May of this year, EMA issued a drug safety risk recommendation. The EMA raised a thyroid cancer safety signal for products including the GLP-1 target for diabetes and obesity drugs. This is a way of monitoring potential adverse events of approved drugs.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Obvious_side_effects\"><\/span>Obvious side effects<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>A client who is engaged in the medical aesthetics industry received an injection of semaglutide, &#8220;I have almost no appetite after the injection, and I don&#8217;t want to eat anything, and I feel overwhelmed after taking a small bite.&#8221; After the injection, there will be reactions such as lethargy and wanting to drink water all the time. Deng Zhidong, general manager of Hainan Boao Medical Technology Co., Ltd., said that most of the weight loss drugs on the market are side effects of weight loss, rather than direct weight loss drugs, so the effect is often not satisfactory.<\/p>\n\n\n\n<p>Unlike those who tried their best to find medicines, another client had an injection as prescribed by the doctor because of his high BMI. The initial dose was 0.25mg, but severe gastrointestinal reactions occurred after adding 0.5mg. &#8220;While losing weight quickly, you were actually dehydrated and couldn&#8217;t concentrate at work at all.&#8221;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Potential_Risks\"><\/span>Potential Risks <span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>In October 2023, a study published in the Journal of the American Medical Association also stated that weight loss drugs such as Wegovy and Ozempic may increase the risk of gastric paralysis, pancreatitis, intestinal obstruction, and biliary tract disease in non-diabetic patients . Please note: Since weight loss drugs such as Wegovy and Ozempic are new generation drugs, the potential risks are still unknown. More medical reports and larger-scale actual clinical results are needed to obtain safer and more accurate confirmation.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"188\" height=\"113\" src=\"https:\/\/www.granitefirm.com\/blog\/us\/wp-content\/uploads\/sites\/2\/2023\/06\/wl-1600x1200-1.jpg\" alt=\"Weight loss\" class=\"wp-image-20329\"\/><figcaption class=\"wp-element-caption\">credit: health.harvard.edu<\/figcaption><\/figure>\n\n\n\n<p><strong><em>I am the author of the original text, and the condensed version of this article was originally published in Smart magazine<\/em><\/strong>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Relative_articles\"><\/span>Relative articles<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2025\/11\/06\/hca-healthcare\/\">How does HCA Healthcare make 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href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/05\/17\/roche\/\">Roche, the king of anti-cancer<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2022\/09\/21\/how-johnson-johnson-make-money\/\" target=\"_blank\" rel=\"noreferrer noopener\">How the best AAA credit rating Johnson &amp; Johnson makes money?<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2022\/04\/04\/intuitive-surgical\/\">How does dominated Intuitive Surgical make money?&#8221;<\/a><\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/01\/16\/improvers-not-inventors\/\">Inventors are rarely successful, but improvers are successful and profitable<\/a>&#8220;<\/li>\n<\/ul>\n\n\n\n<p><em><strong>Disclaimer<\/strong><\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><em>The content of this site is the author\u2019s personal opinions and is for reference only. I am not responsible for the correctness, opinions, and immediacy of the content and information of the article. Readers must make their own judgments.<\/em><\/li>\n\n\n\n<li><em>I shall not be liable for any damages or other legal liabilities for the direct or indirect losses caused by the readers&#8217; direct or indirect reliance on and reference to the information on this site, or all the responsibilities arising therefrom, as a result of any investment behavior.<\/em><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>The blue ocean of weight loss is the future golden goose in the pharmaceutical market, and Monzaro is the future superstar<\/p>\n","protected":false},"author":1,"featured_media":20329,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[120,115],"tags":[958,848,752,504,473,957,474,1005,869,1006],"class_list":["post-20328","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pharmaceutical","category-biotech","tag-amgn","tag-gsk","tag-lly","tag-lvmhf","tag-mrk","tag-nvo","tag-pfe","tag-regn","tag-rhhby","tag-rytm"],"_links":{"self":[{"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/posts\/20328","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/comments?post=20328"}],"version-history":[{"count":80,"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/posts\/20328\/revisions"}],"predecessor-version":[{"id":39815,"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/posts\/20328\/revisions\/39815"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/media\/20329"}],"wp:attachment":[{"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/media?parent=20328"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/categories?post=20328"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/tags?post=20328"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}