{"id":26277,"date":"2024-11-17T23:56:00","date_gmt":"2024-11-17T15:56:00","guid":{"rendered":"https:\/\/www.granitefirm.com\/blog\/us\/?p=26277"},"modified":"2025-11-07T11:25:42","modified_gmt":"2025-11-07T03:25:42","slug":"how-does-crispr-the-gene-editing-inventor-make-money","status":"publish","type":"post","link":"https:\/\/www.granitefirm.com\/blog\/us\/2024\/11\/17\/how-does-crispr-the-gene-editing-inventor-make-money\/","title":{"rendered":"How does CRISPR, the gene editing inventor, make money?"},"content":{"rendered":"\n<p>Please see my post of &#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2024\/11\/02\/gene-editi-casgevy\/\">World\u2019s first gene editing therapy Casgevy finally approved<\/a>&#8221; as affilated article.<\/p>\n\n\n\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #ffffff;color:#ffffff\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #ffffff;color:#ffffff\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2024\/11\/17\/how-does-crispr-the-gene-editing-inventor-make-money\/#Pioneer_of_gene_editing\" >Pioneer of gene editing<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2024\/11\/17\/how-does-crispr-the-gene-editing-inventor-make-money\/#Nobel_Prize_Winner_in_Chemistry\" >Nobel Prize Winner in Chemistry<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2024\/11\/17\/how-does-crispr-the-gene-editing-inventor-make-money\/#Main_products\" >Main products<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2024\/11\/17\/how-does-crispr-the-gene-editing-inventor-make-money\/#Cooperate_with_Vertex\" >Cooperate with Vertex<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2024\/11\/17\/how-does-crispr-the-gene-editing-inventor-make-money\/#Main_competitor\" >Main competitor<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2024\/11\/17\/how-does-crispr-the-gene-editing-inventor-make-money\/#Bluebird_Bio\" >Bluebird Bio<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2024\/11\/17\/how-does-crispr-the-gene-editing-inventor-make-money\/#Latest_quarterly_result\" >Latest quarterly result<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2024\/11\/17\/how-does-crispr-the-gene-editing-inventor-make-money\/#Still_unprofitable\" >Still unprofitable<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2024\/11\/17\/how-does-crispr-the-gene-editing-inventor-make-money\/#Capital_market_performance\" >Capital market performance<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.granitefirm.com\/blog\/us\/2024\/11\/17\/how-does-crispr-the-gene-editing-inventor-make-money\/#Relative_articles\" >Relative articles<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pioneer_of_gene_editing\"><\/span>Pioneer of gene editing<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><a href=\"https:\/\/en.wikipedia.org\/wiki\/CRISPR_Therapeutics\" target=\"_blank\" data-type=\"URL\" data-id=\"https:\/\/en.wikipedia.org\/wiki\/CRISPR_Therapeutics\" rel=\"noreferrer noopener\">CRISPR Therapeutics (ticker: CRSP)<\/a> is a biotech company headquartered in Switzerland. It is one of the first companies to use the CRISPR gene-editing platform to develop drugs for a variety of rare and common diseases.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nobel_Prize_Winner_in_Chemistry\"><\/span>Nobel Prize Winner in Chemistry<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>CRISPR was founded in 2013 by Emmanuelle Charpentier, Shaun Foy and Rodger Novak. [6] Charpentier later shared the 2020 Nobel Prize in Chemistry with Jennifer Doudna. As a member of the working group, she provided the first scientific documentation on the development and use of CRISPR gene editing. This allows DNA to be specifically modified and edited so that it can be used to ameliorate disease. CRISPR is applying this technology platform to research, develop and commercialize drugs to treat a variety of diseases, including sickle cell disease, beta thalassemia, various cancers, type 1 diabetes and cardiovascular disease.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Main_products\"><\/span>Main products<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>CRISPR Therapeutics is developing a variety of drugs to treat blood disorders, cancer, diabetes and other serious diseases.<\/p>\n\n\n\n<p>CRISPR remains on track to start clinical trials for CTX112, a gene-editing treatment for systemic lupus erythematosus. In 2024, in addition to ongoing cancer and autoimmune disorder trials.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Cooperate_with_Vertex\"><\/span>Cooperate with Vertex <span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Since CRISPR is an emerging small biotechnology industry, in order to survive and expand its business, it is no different from other new biotechnology entrepreneurs. It must first find a cooperation with a large international pharmaceutical company to achieve the company&#8217;s business goals.<\/p>\n\n\n\n<p>As a result, Vertex and CRISPR entered into a strategic research collaboration in 2015 focused on using CRISPR\/Cas9 to discover and develop potential new therapies targeting the underlying genetic causes of human disease.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Main_competitor\"><\/span>Main competitor<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Bluebird_Bio\"><\/span>Bluebird Bio<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>The FDA&nbsp;approved Bluebird Biotechnology (ticker: BLUE)\u2019s Lyfgenia&nbsp;for sickle cell disease in December, 2023, along with a&nbsp;rival gene therapy for the disease&nbsp;developed by Vertex Pharmaceuticals and CRISPR Therapeutics.<\/p>\n\n\n\n<p>It has gene-editing treatments for TDT and SCD on the market. But there are three reasons why it should not be a big threat:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>First, Bluebird Biotechnology only operates in the United States. <\/li>\n\n\n\n<li>Second, Vertex is a much larger biotech company than either Bluebird Biotech or CRISPR, and has a track record of negotiating lucrative deals with third-party payers. <\/li>\n\n\n\n<li>Third, Bluebird Biotech\u2019s SCD treatment Lyfgenia carries a boxed warning for blood cancers. In the end, Lyfgenia cost $3.1 million, while Casgevy cost $2.2 million.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Latest_quarterly_result\"><\/span>Latest quarterly result<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Announced &#8220;profitable&#8221; results for the first quarter of 2024 looked more like losses, causing the company to close down 8.5%. CRISPR&#8217;s revenue fell 99.5% year-over-year due to the lack of major milestone payments like those in the first quarter of 2023, and the company reported a loss of $1.43 per share, more than double its loss in the same period last year.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Still_unprofitable\"><\/span>Still unprofitable<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>With only $166.5 million in quarterly&nbsp;negative free cash flow&nbsp;in Q1 2024 report. <\/p>\n\n\n\n<p>However, CRISPR has at least three years before it&#8217;s likely to need additional cash. This is because the company&#8217;s Casgevy treatment for sickle cell anemia, developed in partnership with&nbsp;Vertex Pharmaceuticals has been approved by FDA. It could rely on 40-60 revenue split on sales between CRISPR and Vertex.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Capital_market_performance\"><\/span>Capital market performance<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>CRISPR&#8217;s partner Vertex Pharmaceuticals&#8217; stock price rose by approximately 42.26% in one year in 2023; during the same period, CRISPR Therapeutics rose by 52.68%.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"120\" height=\"131\" src=\"https:\/\/www.granitefirm.com\/blog\/us\/wp-content\/uploads\/sites\/2\/2024\/05\/CRISPR-Custom.png\" alt=\"CRISPR\" class=\"wp-image-26311\"\/><figcaption class=\"wp-element-caption\">credit: Wiki<\/figcaption><\/figure>\n\n\n\n<p><strong><em>I am the author of the original text, the essence of this story was originally featured on Smart Magazine<\/em><\/strong>, <strong><em>Issue of October 2024<\/em><\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Relative_articles\"><\/span>Relative articles<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2025\/11\/06\/hca-healthcare\/\">How does HCA Healthcare make money?<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2025\/10\/18\/chinese-biotech-deepseek\/\">Chinese biotech begins to show its DeepSeek moment<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2025\/09\/16\/akesos-beat-best-drug\/\">Akeso\u2019s lung cancer drug beat world best-selling drug, a biotech DeepSeek watershed<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2024\/11\/02\/gene-editi-casgevy\/\">World\u2019s first gene editing therapy Casgevy finally approved<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2024\/11\/17\/how-does-crispr-the-gene-editing-inventor-make-money\/\">How does CRISPR, the gene editing inventor, make money?<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2024\/11\/29\/how-vertex-make-money\/\">How does rising biotech Vertex make money?<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/11\/15\/eli-lilly-value-king\/\" target=\"_blank\" rel=\"noreferrer noopener\">Why Eli Lilly become global pharmaceutical market value king?<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2024\/06\/28\/gilead-aids-vaccine\/\" target=\"_blank\" rel=\"noreferrer noopener\">Gilead, lord of antiviral drug, reveals world&#8217;s first AIDS vaccine<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2024\/06\/06\/viking\/\" target=\"_blank\" rel=\"noreferrer noopener\">Viking is developing two future star new drugs at the same time<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2024\/06\/02\/mash-breakthrough\/\" target=\"_blank\" rel=\"noreferrer noopener\">FDA approved first ever MASH drug<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/12\/07\/alzheimer-progress\/\" target=\"_blank\" rel=\"noreferrer noopener\">Alzheimer, the only major disease yet to be conquered, current progress and related companies<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/07\/weight-loss-is-golden-goose\/\">Weight loss is the future golden goose of the drug market <\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2022\/11\/29\/big-pharma-spin-offs\/\">Big pharma spin-offs, and advantages to invest them<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/08\/09\/eli-lilly\/\">Eli Lilly, a big pharma with astonishing valuation<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/06\/22\/pfizer-the-largest-pharma\/\">Pfizer, the world&#8217;s largest pharmaceutical company<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/03\/30\/novo-nordisks-new-diabetes-drug-semaglutide-and-incretin-found-to-have-surprising-weight-loss-effects\/\">Novo Nordisk&#8217;s new diabetes drug Semaglutide,Ozempic,Wegovy and Mounjaro found to have surprising weight-loss effects<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2022\/11\/18\/prescription-leader-abbvie\/\">The next No. 1 pharmaceutical leader AbbVie<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2022\/06\/24\/stable-dow-component-merck\/\">Stable Dow Component Merck, how does it make money?<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/11\/06\/the-ex-largest-pharma-merck\/\" target=\"_blank\" rel=\"noreferrer noopener\">The ex-largest pharma Merck<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2022\/07\/02\/abbott-laboratories\/\" target=\"_blank\" rel=\"noreferrer noopener\">Abbott, the world\u2019s most important medical device and nutritional food supplier, how does it make money?<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/05\/17\/roche\/\">Roche, the lord of anti-cancer<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2022\/09\/21\/how-johnson-johnson-make-money\/\" target=\"_blank\" rel=\"noreferrer noopener\">How the best AAA credit rating Johnson &amp; Johnson makes money?<\/a>&#8220;<\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2022\/04\/04\/intuitive-surgical\/\">How does dominated Intuitive Surgical make money?&#8221;<\/a><\/li>\n\n\n\n<li>&#8220;<a href=\"https:\/\/www.granitefirm.com\/blog\/us\/2023\/01\/16\/improvers-not-inventors\/\">Inventors are rarely successful, but improvers are successful and profitable<\/a>&#8220;<\/li>\n<\/ul>\n\n\n\n<p><em><strong>Disclaimer<\/strong><\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><em>The content of this site is the author\u2019s personal opinions and is for reference only. I am not responsible for the correctness, opinions, and immediacy of the content and information of the article. Readers must make their own judgments.<\/em><\/li>\n\n\n\n<li><em>I shall not be liable for any damages or other legal liabilities for the direct or indirect losses caused by the readers&#8217; direct or indirect reliance on and reference to the information on this site, or all the responsibilities arising therefrom, as a result of any investment behavior.<\/em><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>CRISPR is a biotech company headquartered in Switzerland. Founded in 2013 by Emmanuelle Charpentier, Shaun Foy and Rodger Novak. It is the first biotechnology company to use CRISPR gene editing and received world first approved.<\/p>\n","protected":false},"author":1,"featured_media":26311,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[115,114,120],"tags":[1239,1259,1221],"class_list":["post-26277","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biotech","category-new-technology","category-pharmaceutical","tag-blue","tag-csrp","tag-vrtx"],"_links":{"self":[{"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/posts\/26277","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/comments?post=26277"}],"version-history":[{"count":21,"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/posts\/26277\/revisions"}],"predecessor-version":[{"id":39805,"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/posts\/26277\/revisions\/39805"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/media\/26311"}],"wp:attachment":[{"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/media?parent=26277"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/categories?post=26277"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.granitefirm.com\/blog\/us\/wp-json\/wp\/v2\/tags?post=26277"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}