{"id":38158,"date":"2023-12-07T23:56:00","date_gmt":"2023-12-07T15:56:00","guid":{"rendered":"https:\/\/www.granitefirm.com\/blog\/?p=38158"},"modified":"2025-10-19T13:21:09","modified_gmt":"2025-10-19T05:21:09","slug":"%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/","title":{"rendered":"\u963f\u8332\u6d77\u9ed8\u75c7\uff0c\u552f\u4e00\u5c1a\u5f85\u653b\u514b\u7684\u4e3b\u8981\u75be\u75c5\u7684\u76ee\u524d\u9032\u5c55\u548c\u76f8\u95dc\u4f01\u696d"},"content":{"rendered":"\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_86 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"\u986f\u793a\/\u96b1\u85cf\u5167\u5bb9\u76ee\u9304\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #ffffff;color:#ffffff\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #ffffff;color:#ffffff\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E9%98%BF%E8%8C%B2%E6%B5%B7%E9%BB%98%E7%97%87%E7%9A%84%E4%BB%8B%E7%B4%B9\" >\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u4ecb\u7d39<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E7%B0%A1%E4%BB%8B\" >\u7c21\u4ecb<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E6%88%90%E5%9B%A0\" >\u6210\u56e0<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E5%B0%8D%E4%BA%BA%E9%A1%9E%E5%81%A5%E5%BA%B7%E7%9A%84%E6%AE%BA%E5%82%B7%E5%8A%9B\" >\u5c0d\u4eba\u985e\u5065\u5eb7\u7684\u6bba\u50b7\u529b<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E9%87%8D%E8%A6%81%E6%80%A7%E5%A6%82%E4%BD%95%EF%BC%9F\" >\u91cd\u8981\u6027\u5982\u4f55\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E5%B8%82%E5%A0%B4%E6%9C%89%E5%A4%9A%E5%A4%A7\" >\u5e02\u5834\u6709\u591a\u5927<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E6%88%91%E7%9A%84%E6%9B%B8%E4%B8%AD%E6%9C%89%E9%97%9C%E9%98%BF%E8%8C%B2%E6%B5%B7%E9%BB%98%E7%9A%84%E5%85%A7%E5%AE%B9\" >\u6211\u7684\u66f8\u4e2d\u6709\u95dc\u963f\u8332\u6d77\u9ed8\u7684\u5167\u5bb9<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E7%9B%AE%E5%89%8D%E5%B8%82%E5%A0%B4%E7%9A%84%E7%9B%B8%E9%97%9C%E8%97%A5%E5%93%81\" >\u76ee\u524d\u5e02\u5834\u7684\u76f8\u95dc\u85e5\u54c1<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E5%88%B0%E5%BA%95%E6%9C%89%E5%A4%9A%E5%B0%91%E8%97%A5%E7%89%A9%EF%BC%9F\" >\u5230\u5e95\u6709\u591a\u5c11\u85e5\u7269\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E8%91%97%E5%90%8D%E7%9A%84%E9%98%BF%E8%8C%B2%E6%B5%B7%E9%BB%98%E8%97%A5%E7%89%A9%E5%88%97%E8%A1%A8\" >\u8457\u540d\u7684\u963f\u8332\u6d77\u9ed8\u85e5\u7269\u5217\u8868<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#FDA%E5%8A%A0%E9%80%9F%E5%AF%A9%E6%89%B9%E7%9A%84%E8%97%A5%E7%89%A9\" >FDA\u52a0\u901f\u5be9\u6279\u7684\u85e5\u7269<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E9%98%BF%E6%9D%9C%E5%8D%A1%E5%96%AE%E6%8A%97Aduhelm\" >\u963f\u675c\u5361\u55ae\u6297(Aduhelm)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E4%BE%96%E5%8D%A1%E5%A5%88%E5%96%AE%E6%8A%97%EF%BC%88Lecanemab%EF%BC%89\" >\u4f96\u5361\u5948\u55ae\u6297\uff08Lecanemab\uff09<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E9%9D%9E%E5%8A%A0%E9%80%9F%E5%AF%A9%E6%89%B9%E7%9A%84%E8%97%A5%E7%89%A9\" >\u975e\u52a0\u901f\u5be9\u6279\u7684\u85e5\u7269<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E7%82%BA%E4%BD%95%E8%A2%ABFDA%E6%8B%92%E7%B5%95%E5%8A%A0%E9%80%9F%E5%AF%A9%E6%89%B9%EF%BC%9F\" >\u70ba\u4f55\u88abFDA\u62d2\u7d55\u52a0\u901f\u5be9\u6279\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E5%A4%9A%E5%A5%88%E5%96%AE%E6%8A%97%EF%BC%88Donanemab%EF%BC%89\" >\u591a\u5948\u55ae\u6297\uff08Donanemab\uff09<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#RNA%E5%B9%B2%E6%93%BE\" >RNA\u5e72\u64fe<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E5%BD%B1%E9%9F%BF\" >\u5f71\u97ff<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E6%88%90%E6%9C%AC\" >\u6210\u672c<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E5%89%AF%E4%BD%9C%E7%94%A8\" >\u526f\u4f5c\u7528<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E5%B0%8D%E8%B3%87%E6%9C%AC%E5%B8%82%E5%A0%B4%E7%9A%84%E5%BD%B1%E9%9F%BF\" >\u5c0d\u8cc7\u672c\u5e02\u5834\u7684\u5f71\u97ff<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E7%9B%B8%E9%97%9C%E4%BC%81%E6%A5%AD%E7%9A%84%E8%82%A1%E5%83%B9%E8%A1%A8%E7%8F%BE\" >\u76f8\u95dc\u4f01\u696d\u7684\u80a1\u50f9\u8868\u73fe<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E7%A6%AE%E4%BE%86\" >\u79ae\u4f86<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E7%99%BE%E5%81%A5\" >\u767e\u5065<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E5%88%86%E5%B2%90%E7%9A%84%E5%81%A5%E4%BF%9D%E7%B5%A6%E4%BB%98\" >\u5206\u5c90\u7684\u5065\u4fdd\u7d66\u4ed8<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%ef%bc%8c%e5%94%af%e4%b8%80%e5%b0%9a%e5%be%85%e6%94%bb%e5%85%8b%e7%9a%84%e4%b8%bb%e8%a6%81%e7%96%be%e7%97%85%e7%9a%84%e7%9b%ae%e5%89%8d%e9%80%b2%e5%b1%95\/#%E7%9B%B8%E9%97%9C%E6%96%87%E7%AB%A0\" >\u76f8\u95dc\u6587\u7ae0<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%98%BF%E8%8C%B2%E6%B5%B7%E9%BB%98%E7%97%87%E7%9A%84%E4%BB%8B%E7%B4%B9\"><\/span>\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u4ecb\u7d39<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%B0%A1%E4%BB%8B\"><\/span>\u7c21\u4ecb<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u963f\u8332\u6d77\u9ed8\u75c7\uff08Alzheimer\uff09\u4fd7\u7a31\u65e9\u8001\u6027\u7661\u5446\u3001\u8001\u5e74\u7661\u5446\uff0c\u662f\u4e00\u7a2e\u767c\u75c5\u9032\u7a0b\u7de9\u6162\u3001\u96a8\u8457\u6642\u9593\u4e0d\u65b7\u60e1\u5316\u7684\u795e\u7d93\u9000\u5316\u6027\u75be\u75c5\uff0c\u6b64\u75c5\u75c7\u4f54\u4e86\u5931\u667a\u75c7\u4e2d\u516d\u5230\u4e03\u6210\u7684\u6210\u56e0\uff0c\u6700\u5e38\u898b\u7684\u65e9\u671f\u75c7\u72c0\u70ba\u55aa\u5931\u77ed\u671f\u8a18\u61b6\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%88%90%E5%9B%A0\"><\/span>\u6210\u56e0<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u771f\u6b63\u6210\u56e0\u81f3\u4eca\u4ecd\u7136\u4e0d\u660e\u3002\u76ee\u524d\u5c07\u963f\u8332\u6d77\u9ed8\u75c7\u8996\u70ba\u4e00\u7a2e\u795e\u7d93\u9000\u5316\u7684\u75be\u75c5\uff0c\u4e26\u8a8d\u70ba\u6709\u5c07\u8fd1\u4e03\u6210\u7684\u98a8\u96aa\u56e0\u5b50\u8207\u907a\u50b3\u6709\u95dc\uff1b\u5176\u4ed6\u7684\u98a8\u96aa\u56e0\u5b50\u9084\u6709\u982d\u90e8\u5916\u50b7\u3001\u6182\u9b31\u75c7\u548c\u9ad8\u8840\u58d3\u3002<\/p>\n\n\n\n<p>\u4f46\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u767c\u5c55\u8207\u5927\u8166\u4e2d\u7684\u7e96\u7dad\u72c0\u985e\u6fb1\u7c89\u86cb\u767d\u8cea\u6591\u584a\uff08\u03b2\u985e\u6fb1\u7c89\u6a23\u86cb\u767d\uff09\u6c89\u7a4d\u548cTau\u86cb\u767d\u6709\u95dc\u3002\u03b2\u985e\u6fb1\u7c89\u6a23\u86cb\u767d\u6703\u7d50\u6210\u584a\uff0c\u8b8a\u6210\u5927\u8166\u4e2d\u7684\u6591\u584a\uff0c\u5c0d\u5927\u8166\u7d30\u80de\u6709\u5bb3\uff0c\u75c5\u4eba\u56e0\u70ba\u5927\u8166\u4e2d\u4e0d\u6b63\u5e38\u7684\u985e\u6fb1\u7c89\u86cb\u767d\u7684\u7d2f\u7a4d\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B0%8D%E4%BA%BA%E9%A1%9E%E5%81%A5%E5%BA%B7%E7%9A%84%E6%AE%BA%E5%82%B7%E5%8A%9B\"><\/span>\u5c0d\u4eba\u985e\u5065\u5eb7\u7684\u6bba\u50b7\u529b<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u963f\u8332\u6d77\u9ed8\u75c7\u662f\u5931\u667a\u7684\u4e3b\u56e0\uff0c\u5931\u667a\u75c7\u60a3\u8005\u7684\u8a18\u61b6\u3001\u601d\u8003\u6216\u6c7a\u7b56\u80fd\u529b\u7686\u53d7\u640d\uff0c\u5e72\u64fe\u65e5\u5e38\u6d3b\u52d5\u3002\u5c31\u76ee\u524d\u4eba\u985e\u7684\u91ab\u5b78\u6280\u8853\u800c\u8a00\uff0c\u4e00\u65e6\u75c5\u4eba\u767c\u73fe\u963f\u8332\u6d77\u9ed8\u75c7\uff0c\u75c7\u72c0\u53ea\u6703\u96a8\u5e74\u7d00\u52a0\u5287\u5b8c\u5168\u6c92\u6709\u6062\u6062\u7684\u53ef\u80fd\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%87%8D%E8%A6%81%E6%80%A7%E5%A6%82%E4%BD%95%EF%BC%9F\"><\/span>\u91cd\u8981\u6027\u5982\u4f55\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u963f\u8332\u6d77\u9ed8\u662f\u552f\u4e00\u5c1a\u5f85\u653b\u514b\u7684\u4e3b\u8981\u75be\u75c5\uff0c\u662f\u5c0e\u81f4\u5168\u7403\u7b2c\u4e03\u5927\u6b7b\u56e0\u300c\u5931\u667a\u75c7\u300d\u7684\u5143\u5147\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B8%82%E5%A0%B4%E6%9C%89%E5%A4%9A%E5%A4%A7\"><\/span>\u5e02\u5834\u6709\u591a\u5927<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u7d0485\u842c\u82f1\u570b\u4eba\u548c580\u842c\u7f8e\u570b\u4eba\u60a3\u6709\u963f\u8332\u6d77\u9ed8\u75c7\uff0c\u8a72\u75be\u75c5\u662f\u5931\u667a\u7684\u4e3b\u56e0\uff0c\u5931\u667a\u75c7\u60a3\u8005\u7684\u8a18\u61b6\u3001\u601d\u8003\u6216\u6c7a\u7b56\u80fd\u529b\u7686\u53d7\u640d\uff0c\u5e72\u64fe\u65e5\u5e38\u6d3b\u52d5\u3002\u7f8e\u570b\u963f\u8332\u6d77\u9ed8\u75c7\u5354\u6703\u516c\u4f48\u904e\u7f8e\u570b\u6709650\u842c\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\u53ca\u5176\u5bb6\u5ead\uff0c\u4e26\u4e14\u9810\u671f\u6703\u57282050\u5e74\u589e\u52a0\u52301500\u842c\u2f08\u3002<\/p>\n\n\n\n<p>\u65e5\u672c\u7684\u570b\u969b\u963f\u8332\u6d77\u9ed8\u75c7\u5354\u6703\u6307\u51fa\uff0c\u76ee\u524d\u5168\u7403\u67095000\u842c\u540d\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\uff0c\u5230\u4e862050\u5e74\u53ef\u80fd\u589e\u70ba1\u51045000\u842c\u4eba\u3002<\/p>\n\n\n\n<p>\u4e2d\u570b\u88ab\u4f30\u8a08\u5927\u7d04\u670921 10\u842c\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\uff0c\u60a3\u75c5\u7387\u662f1990\u5e74\u76849.59\u500d\u3002<\/p>\n\n\n\n<p>\u82f1\u570b\u570b\u5bb6\u7d71\u8a08\u5c40(ONS)4\u6708\u7684\u4e00\u4efd\u7814\u7a76\u63ed\u9732\uff0c\u5931\u667a\u8207\u963f\u8332\u6d77\u9ed8\u75c7\u662f\u82f1\u570b2022\u5e74\u7684\u6b7b\u4ea1\u4e3b\u56e0\uff0c\u7d04\u53606\u842c5967\u500b\u6b7b\u4ea1\u6848\u4f8b\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dementia\" target=\"_blank\" rel=\"noreferrer noopener\">2015\u5e74WHO\u66fe\u516c\u4f48\u904e\u8cc7\u6599\uff0c\u5168\u7403\u5927\u7d04\u67092980\u842c\u4eba\u7f79\u60a3\u963f\u8332\u6d77\u9ed8\u75c7<\/a>\u3002WHO\u9810\u6e2c\uff0c\u52302050\u5e74\u5168\u7403\u5c07\u67091.5\u5104\u4eba\u5931\u667a\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%88%91%E7%9A%84%E6%9B%B8%E4%B8%AD%E6%9C%89%E9%97%9C%E9%98%BF%E8%8C%B2%E6%B5%B7%E9%BB%98%E7%9A%84%E5%85%A7%E5%AE%B9\"><\/span>\u6211\u7684\u66f8\u4e2d\u6709\u95dc\u963f\u8332\u6d77\u9ed8\u7684\u5167\u5bb9<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u6211\u5728\u6700\u8fd1\u51fa\u7248\u7684\u300a<a href=\"https:\/\/www.books.com.tw\/products\/0010935641?sloc=main\" target=\"_blank\" rel=\"noreferrer noopener\">10\u500d\u80a1\u6cd5\u5247<\/a>\u300b\u4e00\u66f8\u4e2d\u88e1\uff0c\u8a0e\u8ad6\u904e\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u767c\u5c55\u548c\u76f8\u95dc\u516c\u53f8\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>3-4\u7bc0\uff0c\u7b2c141\u9801<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%9B%AE%E5%89%8D%E5%B8%82%E5%A0%B4%E7%9A%84%E7%9B%B8%E9%97%9C%E8%97%A5%E5%93%81\"><\/span>\u76ee\u524d\u5e02\u5834\u7684\u76f8\u95dc\u85e5\u54c1<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%88%B0%E5%BA%95%E6%9C%89%E5%A4%9A%E5%B0%91%E8%97%A5%E7%89%A9%EF%BC%9F\"><\/span>\u5230\u5e95\u6709\u591a\u5c11\u85e5\u7269\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u5230\u76ee\u524d\u70ba\u6b62\uff0cFDA\u53ea\u6838\u6dee\u4e867\u7a2e\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u56db\u7a2e\u81bd\u9e7c\u916f\u9176\u6291\u88fd\u5291\uff08cholinesterase inhibitors\uff09<\/li>\n\n\n\n<li>\u827e\u4f2f\u7dad\u7684NMDA\u53d7\u9ad4(N-methyl-D-aspartate)<\/li>\n\n\n\n<li>\u767e\u5065\u53ca\u5176\u885b\u91c7\uff08Eisai\uff09\u7684\u5169\u7a2e\u52a0\u901f\u5be9\u6279\u7684\u85e5\u7269<\/li>\n<\/ul>\n\n\n\n<p>\u53e6\u4e00\u7a2e\u5f88\u53ef\u80fd\u5c07\u6703\u88ab\u6838\u6dee\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u79ae\u4f86\u7814\u767c\u7684Donanemab\u55ae\u682a\u6297\u9ad4<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%91%97%E5%90%8D%E7%9A%84%E9%98%BF%E8%8C%B2%E6%B5%B7%E9%BB%98%E8%97%A5%E7%89%A9%E5%88%97%E8%A1%A8\"><\/span>\u8457\u540d\u7684\u963f\u8332\u6d77\u9ed8\u85e5\u7269\u5217\u8868<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>FDA\u5230\u76ee\u524d\u70ba\u6b62\u53ea\u6838\u6dee\u4e867\u7a2e\u85e5\u7269\uff0c\u8a73\u898b\u8868\u4e00\u7684\u5167\u5bb9\u3002\u800c\u672c\u6587\u5f8c\u534a\u6240\u8a0e\u8ad6\u7684\u5247\u662f\u6700\u8fd1\u5e7e\u5e74\u6700\u71b1\u9580\uff0cFDA\u5df2\u6838\u6dee\u6216\u5373\u5c07\u6838\u6dee\u7684\u8f03\u65b0\u4e00\u4ee3\u7684\u55ae\u682a\u6297\u9ad4\u548cRNA\u7642\u6cd5\u65b0\u85e5\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>\u5b78\u540d<\/td><td>\u85e5\u5546<\/td><td>\u85e5\u54c1\u7a2e\u985e<\/td><td>\u526f\u4f5c\u7528<\/td><\/tr><tr><td>\u52a0\u862d\u4ed6\u654f\uff08Galantamine\uff09<\/td><td>\u5b0c\u751f<\/td><td>\u81bd\u9e7c\u916f\u9176\u6291\u88fd\u5291\uff08Cholinesterase inhibitors\uff09<\/td><td>\u5641\u5fc3\u3001\u5614\u5410\u3001\u8179\u7009\u53ca\u98df\u617e\u6e1b\u9000<\/td><\/tr><tr><td>\u5361\u5df4\u62c9\u6c40\uff08Rivastigmine\uff09<\/td><td>\u8afe\u83ef<\/td><td>\u81bd\u9e7c\u916f\u9176\u6291\u88fd\u5291\uff08Cholinesterase inhibitors\uff09<\/td><td>\u5641\u5fc3\u3001\u5614\u5410\u3001\u8179\u7009\u53ca\u98df\u617e\u6e1b\u9000<\/td><\/tr><tr><td>\u591a\u5948\u54cc\u9f4a\uff08Donepezil\uff09<\/td><td>\u8f1d\u745e<\/td><td>\u81bd\u9e7c\u916f\u9176\u6291\u88fd\u5291\uff08Cholinesterase inhibitors\uff09<\/td><td>\u5641\u5fc3\u3001\u5614\u5410\u3001\u8179\u7009\u53ca\u98df\u617e\u6e1b\u9000<\/td><\/tr><tr><td>NMDA\u53d7\u9ad4(N-methyl-D-aspartate)<\/td><td>\u827e\u4f2f\u7dad<\/td><td>\u6291\u5236\u9223\u96e2\u5b50\u5c0d\u8166\u90e8\u795e\u7d93\u5143\u7684\u6bd2\u7d20\u4f5c<br>\u7528\u7684\u62ee\u6297\u5291<\/td><td>\u5e7b\u89ba\u3001\u56f0\u60d1\u3001\u6688\u7729\u3001\u982d\u75db\u3001\u75b2\u5026\u7b49<\/td><\/tr><tr><td>\u9e7d\u9178\u591a\u5948\u54cc\u9f4a\uff08Donepezil Hydrochloride)<\/td><td>\u827e\u4f2f\u7dad<\/td><td>\u901a\u904e\u589e\u5f37\u81bd\u9e7c\u80fd\u795e\u7d93\u7684\u529f\u80fd\u767c\u63ee\u6cbb\u7642\u4f5c\u7528<\/td><td>\u5fc3\u3001\u8179\u7009\u3001\u5931\u7720\u3001\u5614\u5410\u3001\u808c\u8089\u75d9\u6523\u3001\u4e4f\u529b\u3001\u5026\u6020\u8207\u98df\u617e\u6e1b\u9000<\/td><\/tr><tr><td>\u963f\u675c\u5361\u55ae\u6297\uff08Aducanumab\uff09<\/td><td>\u767e\u5065\u53ca\u885b\u91c7<\/td><td>\u55ae\u682a\u6297\u9ad4<\/td><td>\u8166\u816b\u8139\u767c\u751f\u738712.6%\uff0c\u51fa\u8840\u738717.3%<\/td><\/tr><tr><td>\u6a02\u5361\u5948\u55ae\u6297\uff08Lecanemab\uff09<\/td><td>\u767e\u5065\u53ca\u885b\u91c7<\/td><td>\u55ae\u682a\u6297\u9ad4<\/td><td>\u8166\u816b\u8139\u548c\u8166\u51fa\u8840\uff0c\u7a31\u70ba\u985e\u6fb1\u7c89\u86cb\u767d\u76f8\u95dc\u5f71\u50cf\u7570\u5e38\uff08ARIA\uff09<\/td><\/tr><tr><td>\u591a\u5948\u55ae\u6297\uff08Donanemab\uff09<\/td><td>\u79ae\u4f86<\/td><td>\u55ae\u682a\u6297\u9ad4<\/td><td>ARIA\uff0c\u56b4\u91cd\u7684ARIA\u767c\u751f\u7387\u4ecd\u67091.6%<\/td><\/tr><tr><td>ALN-APP\u57fa\u56e0\u975c\u9ed8(Gene Silencing)\u7642\u6cd5<\/td><td>Alnylam Pharmaceuticals<\/td><td>RNA\u5e72\u64fe\u963b\u65b7\u86cb\u767d\u8cea\u7684\u7522\u751f<\/td><td>\u526f\u4f5c\u7528\u5f88\u8f15\u5fae<\/td><\/tr><\/tbody><\/table><figcaption class=\"wp-element-caption\">(\u8cc7\u6599\u4f86\u6e90\uff1aFDA\uff0c\u5404\u85e5\u5ee0\uff0c\u5a92\u9ad4\u5831\u5c0e)<\/figcaption><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"FDA%E5%8A%A0%E9%80%9F%E5%AF%A9%E6%89%B9%E7%9A%84%E8%97%A5%E7%89%A9\"><\/span>FDA\u52a0\u901f\u5be9\u6279\u7684\u85e5\u7269<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>FDA \u5df2\u52a0\u901f\u6279\u51c6\u5169\u7a2e\u53ef\u80fd\u6e1b\u7de9\u963f\u8332\u6d77\u9ed8\u75c7\u9032\u5c55\u4e14\u50c5\u9069\u7528\u65bc\u8f15\u5ea6\u75be\u75c5\u60a3\u8005\u7684\u85e5\u7269\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6a02\u5361\u5948\u55ae\u6297 (Lequembi\u00ae)<\/li>\n\n\n\n<li>\u963f\u675c\u5361\u55ae\u6297 (Aduhelm\u00ae)<\/li>\n<\/ul>\n\n\n\n<p>\u9019\u4e9b\u85e5\u7269\u7684\u76ee\u6a19\u662f\u53bb\u9664\u5927\u8166\u6fb1\u7c89\u6a23\u86cb\u767d\uff0c\u9019\u662f\u963f\u8332\u6d77\u9ed8\u75c7\u75c5\u60a3\u8005\u5927\u8166\u4e2d\u7a4d\u805a\u7684\u86cb\u767d\u8cea\u4e4b\u4e00\u3002 \u5728\u958b\u59cb\u4f7f\u7528\u9019\u4e9b\u85e5\u7269\u4e4b\u524d\uff0c\u60a8\u7684\u91ab\u751f\u9700\u8981\u78ba\u8a8d\u60a8\u7684\u5927\u8166\u4e2d\u662f\u5426\u5b58\u5728\u6fb1\u7c89\u6a23\u86cb\u767d\u3002 \u60a8\u7684\u91ab\u751f\u6703\u8981\u6c42\u9032\u884c\u6fb1\u7c89\u6a23\u86cb\u767d PET \u6383\u63cf\u6216\u810a\u690e\u7a7f\u523a\u3002<\/p>\n\n\n\n<p>Lecanemab \u548c aducanumab \u5c0d\u65e9\u671f\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\u7684\u5f71\u97ff\u4ecd\u5728\u7814\u7a76\u4e2d\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%98%BF%E6%9D%9C%E5%8D%A1%E5%96%AE%E6%8A%97Aduhelm\"><\/span>\u963f\u675c\u5361\u55ae\u6297(Aduhelm)<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u767e\u5065\uff08\u7f8e\u80a1\u4ee3\u78bc\uff1aBIIB\uff09\u5728 2021 \u5e74\u88ab FDA \u6838\u53ef\u4e0a\u5e02\uff0c\u662f\u8fd1\u5eff\u5e74\u4f86\u7b2c\u4e00\u7a2e\u88ab\u6838\u6dee\u7684\u963f\u8332\u6d77\u9ed8\u75c7\u65b0\u85e5\u30021 \u5e74\u85e5\u50f9\u8a02\u5728\u6bcf\u4eba 5 \u842c 6,000 \u7f8e\u5143\u7684\u963f\u8332\u6d77\u9ed8\u75c7\u65b0\u85e5 Aduhelm \u5145\u6eff\u722d\u8b70\uff0c\u4e0a\u5e02\u5f8c\u81e8\u5e8a\u91ab\u5e2b\u958b\u85e5\u7387\u51fa\u5947\u7684\u4f4e\uff1b\u64daFactSet\uff08\u7f8e\u80a1\u4ee3\u78bc\uff1aFDS\uff09\u7684\u7d71\u8a08\uff0c\u7372\u51c6\u4e0a\u5e02\u5f8c\u7684\u7b2c 1 \u500b\u5b63\u5ea6\u92b7\u552e\u984d\u50c5 30 \u842c\u7f8e\u5143\uff0c\u9060\u9060\u4e0d\u53ca\u9810\u4f30\u7684 1,200 \u842c\u7f8e\u5143\u3002\u591a\u5bb6\u77e5\u540d\u7684\u9818\u982d\u91ab\u9662\u62d2\u7d55\u63a1\u7528\uff0c\u5177\u5f71\u97ff\u529b\u7684\u5c08\u696d\u91ab\u7642\u59d4\u54e1\u6703\u4e5f\u6295\u7968\u5426\u6c7a\u8a72\u85e5\u6548\u529b\uff0c\u800c\u91ab\u7642\u4fdd\u96aa\u696d\u8005\u4e5f\u5728\u7b49\u5f85\u806f\u90a6\u91ab\u7642\u4fdd\u96aa\u767c\u5e03\u7684\u627f\u4fdd\u689d\u4ef6\uff0c\u624d\u6703\u505a\u51fa\u662f\u5426\u7d0d\u4fdd\u7684\u6c7a\u5b9a\u3002<\/p>\n\n\n\n<p>\u4f46\u767e\u5065\u53ca\u5176\u65e5\u672c\u5408\u4f5c\u5925\u4f34\u885b\u91c7\uff08Eisai\uff09\u65bc\u524d\u5e742021\u5e746\u67087\u65e5\uff0c\u7372\u5f97FDA\u6279\u51c6\u7684\u963f\u8332\u6d77\u9ed8\u65b0\u85e5Aduhelm\uff0c\u537b\u906d\u9047\u5230\u91ab\u754c\u8207\u5e02\u5834\u5c0d\u8a72\u85e5\u5b89\u5168\u6027\u7684\u7591\u616e\u3002\u773e\u8b70\u9662\u76e3\u7763\u548c\u6539\u9769\u59d4\u54e1\u6703\uff0c\u4ee5\u53ca\u80fd\u6e90\u548c\u5546\u52d9\u59d4\u54e1\u6703\uff0c\u91dd\u5c0d\u806f\u90a6\u98df\u54c1\u66a8\u85e5\u7269\u7ba1\u7406\u5c40\u5be9\u6838\u3001\u5b9a\u50f9\u548c\u884c\u92b7Aduhelm\u63d0\u51fa\u5831\u544a\u6307\u51fa\uff0c\u5176\u904e\u7a0b\u300c\u5145\u65a5\u7740\u4e0d\u7b26\u5408\u898f\u7bc4\u7684\u884c\u70ba\u300d\uff0c\u5be9\u6838\u524d\u8207\u85e5\u5ee0\u65b9\u9762\u7684\u63a5\u89f8\uff0c\u672a\u9075\u5b88FDA\u7684\u5167\u90e8\u6307\u5f15\u53ca\u6163\u4f8b\uff0c\u63d0\u51fa\u516b\u5927\u7591\u9ede\u3002<\/p>\n\n\n\n<p>Aducanumab\u6700\u521d\u70ba\u6bcf\u5e7456,000\u7f8e\u5143\uff0c\u4e26\u672a\u5f97\u5230\u4fdd\u96aa\u516c\u53f8\u7684\u627f\u4fdd\uff0c\u4e14\u5df2\u7d93\u88ab\u8a31\u591a\u570b\u5bb6\u7684\u76e3\u7ba1\u6a5f\u69cb\u62d2\u7d55\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E4%BE%96%E5%8D%A1%E5%A5%88%E5%96%AE%E6%8A%97%EF%BC%88Lecanemab%EF%BC%89\"><\/span>\u4f96\u5361\u5948\u55ae\u6297\uff08Lecanemab\uff09<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>2022\u5e747\u6708\uff0c\u767e\u5065\uff08\u7f8e\u80a1\u4ee3\u78bc\uff1aBIIB\uff09\u548c\u885b\u91c7\u6b63\u5f0f\u5411FDA\u7533\u8acbLecanemab\u52a0\u901f\u5be9\u6279\u3002\u57fa\u65bc\u4e00\u7a2e\u85e5\u7269\u6709\u671b\u6bd4\u73fe\u6709\u85e5\u7269\u66f4\u6709\u6548\u5730\u5e6b\u52a9\u60a3\u6709\u56b4\u91cd\u75be\u75c5\u7684\u60a3\u8005\uff0cFDA\u53ef\u4ee5\u52a0\u5feb\u6279\u51c6\u4e00\u7a2e\u85e5\u7269\uff0c\u4ee5\u4fbf\u8fc5\u901f\u5c07\u5176\u63a8\u5411\u5e02\u5834\u3002\u7f8e\u570b\u806f\u90a6\u98df\u54c1\u66a8\u85e5\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u65bc2023\u5e741\u67086\u65e5\u52a0\u901f\u6279\u51c6\uff08Accelerated Approval pathway\uff09\u4e86\u963f\u8332\u6d77\u9ed8\u75c7\u65b0\u85e5Lecanemab\uff08\u4f96\u5361\u5948\u55ae\u6297\uff09\uff0c\u800c\u5546\u54c1\u540d\u662fLeqembi\u3002<a href=\"https:\/\/jamanetwork.com\/journals\/jama\/article-abstract\/2807654#:~:text=Lecanemab%2Dirmb%2C%20marketed%20by,Drug%20Administration%20(FDA)%20announced.\" target=\"_blank\" rel=\"noreferrer noopener\">2023\u5e746\u6708\u66f4\u5df2\u7d93\u7372\u5f97\u4e86FDA\u7684\u5168\u9762\u4e0a\u5e02\u6279\u51c6<\/a>\u3002<\/p>\n\n\n\n<p>\u96d6\u7136Lecanemab\u5728\u6cbb\u7642\u4e0a\u4e5f\u6709\u8166\u816b\u8139\u548c\u51fa\u8840\u7684\u98a8\u96aa\uff0c\u4f46FDA\u4ecd\u6839\u64da\u53bb\u5e7411\u6708\u6240\u767c\u8868\u7684\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\uff0cLecanemab\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u6e1b\u7de9\u4e86\u56e0\u963f\u8332\u6d77\u9ed8\u75c7\u800c\u8f15\u5ea6\u53d7\u640d\u7684\u60a3\u8005\u7684\u8a8d\u77e5\u80fd\u529b\u4e0b\u964d\uff0c\u52a0\u901f\u6279\u51c6Lecanemab\u3002<\/p>\n\n\n\n<p>Lecanemab\u65b0\u85e5\u7642\u6548\uff1a\u300c\u9069\u5ea6\u300d\u5ef6\u7de9\u75be\u75c5\uff0c\u4e0d\u662f\u6cbb\u7652Lecanemab\u662f\u4e00\u7a2e\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u9776\u5411\u963f\u8332\u6d77\u9ed8\u75c7\u60a3\u8005\u5927\u8166\u4e2d\u7a4d\u805a\u7684\u985e\u6fb1\u7c89\u86cb\u767d\uff0c\u4e0d\u662f\u6cbb\u7652\uff08not a cure\uff09\uff0c\u800c\u662f\u901a\u904e\u8207\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u6a19\u8a8c\u03b2\u985e\u6fb1\u7c89\u86cb\u767d\u7d50\u5408\u8d77\u4f5c\u7528Lecanemab\u9019\u7a2e\u6cbb\u7642\u65b9\u6848\u662f\u91dd\u5c0d\u5f71\u97ff\u963f\u8332\u6d77\u9ed8\u75c7\u6f5b\u5728\u75be\u75c5\u904e\u7a0b\u7684\u6700\u65b0\u7642\u6cd5\uff0c\u800c\u4e0d\u50c5\u50c5\u662f\u6cbb\u7642\u75be\u75c5\u7684\u75c7\u72c0\u3002\u5982\u679c\u9019\u4e9b\u8a66\u9a57\u8b49\u5be6\u8a72\u85e5\u7269\u5177\u6709\u81e8\u5e8a\u76ca\u8655\u3002\u9019\u7a2e\u6297\u9ad4\u6bcf\u5169\u5468\u975c\u8108\u6ce8\u5c04\u4e00\u6b21\uff0c\u5291\u91cf\u662f\u6839\u64da\u60a3\u8005\u9ad4\u91cd\u6c7a\u5b9a\uff0c\u6bcf\u516c\u65a4\u6ce8\u5c0410\u6beb\u514b\u3002<\/p>\n\n\n\n<p>Lecanemab\u7d44\u4e2d\u6700\u5e38\u898b\u7684\u4e0d\u826f\u4e8b\u4ef6\u662f\u5c0d\u975c\u8108\u8f38\u6ce8\u7684\u53cd\u61c9\u548c\u78c1\u632f\u9020\u5f71\uff08MRI\uff09\u7570\u5e38\uff0c\u4f8b\u5982\u8166\u816b\u8139\u548c\u8166\u51fa\u8840\uff0c\u7a31\u70ba\u985e\u6fb1\u7c89\u86cb\u767d\u76f8\u95dc\u5f71\u50cf\u7570\u5e38\uff08ARIA\uff0camyloid-related imaging abnormalities\uff09\uff0c\u9019\u53ef\u80fd\u5371\u53ca\u751f\u547d\u3002<\/p>\n\n\n\n<p>Lecanemab\u6bcf\u5e74\u7684\u8cbb\u7528\u7d04\u70ba26,500\u7f8e\u5143\uff0c\u6548\u679c\u5e7e\u4e4e\u8207donanemab\u4e00\u6a23\u512a\u79c0\u3002<\/p>\n\n\n\n<p>2023\u5e747\u6708\u4e0a\u65ec\uff0c\u7f8e\u570b\u98df\u54c1\u66a8\u85e5\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u6279\u51c6\u9019\u6b3e\u963f\u8332\u6d77\u9ed8\u75c7\u65b0\u85e5\u3002<\/p>\n\n\n\n<p>2023\u5e748\u6708\uff0c\u65e5\u672c\u6b63\u5f0f\u6838\u51c6Lecanemab\u5728\u65e5\u672c\u4e0a\u5e02\uff0c\u9019\u662f\u65e5\u672c\u5883\u5167\u9996\u5ea6\u6709\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u85e5\u7269\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%9D%9E%E5%8A%A0%E9%80%9F%E5%AF%A9%E6%89%B9%E7%9A%84%E8%97%A5%E7%89%A9\"><\/span>\u975e\u52a0\u901f\u5be9\u6279\u7684\u85e5\u7269<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%82%BA%E4%BD%95%E8%A2%ABFDA%E6%8B%92%E7%B5%95%E5%8A%A0%E9%80%9F%E5%AF%A9%E6%89%B9%EF%BC%9F\"><\/span>\u70ba\u4f55\u88abFDA\u62d2\u7d55\u52a0\u901f\u5be9\u6279\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p><a href=\"https:\/\/www.fiercebiotech.com\/biotech\/eli-lilly-shut-out-alzheimers-fast-lane-complete-response-letter-donanemab#:~:text=Eli%20Lilly&#039;s%20bid%20for%20an,cases%20of%20symptomatic%20Alzheimer&#039;s%20disease.\" target=\"_blank\" rel=\"noreferrer noopener\">\u79ae\u4f86\u516c\u53f8\u52a0\u901f\u6279\u51c6\u963f\u8332\u6d77\u9ed8\u75c7\u85e5\u7269\u591a\u7d0d\u5948\u55ae\u6297\u7684\u7533\u8acb\u5df2\u88ab FDA \u53eb\u505c<\/a>\u3002<\/p>\n\n\n\n<p>\u64da\u79ae\u4f86\u516c\u53f8\u7a31\uff0cFDA \u62d2\u7d55\u4e86\u79ae\u4f86\u516c\u53f8\u7684\u8acb\u6c42\uff0c\u56e0\u70ba\u5728\u81e8\u5e8a\u7814\u7a76\u4e2d\u7d93\u6b77\u904e\u81f3\u5c11 12 \u500b\u6708\u85e5\u7269\u66b4\u9732\u7684\u60a3\u8005\u6578\u91cf\u6709\u9650\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%A4%9A%E5%A5%88%E5%96%AE%E6%8A%97%EF%BC%88Donanemab%EF%BC%89\"><\/span>\u591a\u5948\u55ae\u6297\uff08Donanemab\uff09<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>2023\u5e745\u67083\u65e5\uff0c\u79ae\u4f86\uff08\u7f8e\u80a1\u4ee3\u78bc\uff1aLLY\uff09\u6700\u65b0\u516c\u4f48\u7684\u81e8\u5e8a\u6578\u64da\u986f\u793a\uff0cDonanemab\u55ae\u682a\u6297\u9ad4\u6709\u8d85\u8d8aLecanemab\u7684\u6f5b\u529b\uff1bdonanemab\u662f\u4e00\u7a2e\u6297\u9ad4\uff0c\u5176\u6a19\u9776\u662f\u4e00\u7a2e\u86cb\u767d\u8cea\u300c\u03b2-\u6fb1\u7c89\u6a23\u86cb\u767d\u300d\u3002\u5728\u81e8\u5e8a\u7d50\u679c\u4e2d\uff0cDonanemab\u7642\u6548\u4f3c\u4e4e\u66f4\u4f54\u512a\u52e2\u3002\u88ab\u8b49\u5be6\u53ef\u6e05\u9664\u8166\u4e2d\u4e0d\u6b63\u5e38\u7684\u985e\u6fb1\u7c89\u86cb\u767d\u3002donanemab\u6bcf\u500b\u6708\u9700\u8981\u65bd\u7528\u6578\u6b21\u3002<\/p>\n\n\n\n<p>\u6839\u64da\u79ae\u4f86\u8868\u8ff0\uff0c\u9019\u662f\u963f\u723e\u8328\u6d77\u9ed8\u75c5\u85e5\u7269\u9996\u6b21\u57283\u671f\u8a66\u9a57\u4e2d\uff0c\u5c07\u60a3\u8005\u7684\u8a8d\u77e5\u8870\u9000\u5e45\u5ea6\u6e1b\u7de935%\u4ee5\u4e0a\u3002\u7684\u78ba\uff0c\u55ae\u7d14\u5f9e\u6578\u5b57\u4f86\u770b\uff0cDonanemab\u8981\u512a\u65bclecanemab\u3002\u4e09\u671f\u7d50\u679c\u986f\u793a\uff0c\u5728\u63a5\u53d7\u6cbb\u764218\u500b\u6708\u5f8c\uff0clecanemab\u7d44\u7684CDR-SB\u8a55\u5206\u6bd4\u5b89\u7a69\u5291\u7d44\u4f4e\u4e8627%\u3002<\/p>\n\n\n\n<p>\u79ae\u4f86\u5df2\u5411\u98df\u54c1\u548c\u85e5\u7269\u7ba1\u7406\u5c40(FDA)\u7533\u8acb\u5be9\u6279\uff0c \u82e5\u7372\u6279\u51c6\uff0c\u5c07\u662f\u7e7c\u767e\u5065\uff08\u7f8e\u80a1\u4ee3\u78bc\uff1aBIIB\uff09\u548c\u885b\u91c7\u6b63\u5f0f\u5411FDA\u7533\u8acbLecanemab\u6700\u8fd1\u7372FDA\u6279\u51c6\u7684\u4f96\u5361\u5948\u55ae\u6297\uff08Lecanemab\uff09\u548cAduhelm\u5f8c\uff0c\u7b2c\u4e09\u7a2e\u88ab\u8b49\u660e\u53ef\u4ee5\u5ef6\u7de9\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u85e5\u7269\u3002<\/p>\n\n\n\n<p>\u96d6\u7136Donanemab\u6cbb\u7642\u7d44\u5927\u591a\u6578\u526f\u4f5c\u7528\u70ba\u8f15\u5ea6\u81f3\u4e2d\u5ea6\uff0c\u901a\u904e\u9069\u7576\u8655\u7406\u5df2\u6d88\u9000\u6216\u7a69\u5b9a\uff0c\u4f46\u6fb1\u7c89\u6a23\u86cb\u767d\u76f8\u95dc\u5f71\u50cf\u5b78\u7570\u5e38\uff08ARIA\uff09\uff0c\u662f\u85e5\u7269\u6700\u53d7\u95dc\u6ce8\u7684\u4e0d\u826f\u53cd\u61c9\u3002\u56b4\u91cd\u7684ARIA\u767c\u751f\u7387\u4ecd\u67091.6%\u3002\u5176\u4e2d2\u540d\u60a3\u8005\u751a\u81f3\u56e0ARIA\u6b7b\u4ea1\uff0c\u9084\u67091\u4f8b\u5728\u56b4\u91cdARIA\u5f8c\u6b7b\u4ea1\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"RNA%E5%B9%B2%E6%93%BE\"><\/span>RNA\u5e72\u64fe<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u76ee\u524d\u963f\u8332\u6d77\u9ed8\u75c7\u65b0\u85e5Donanemab\u3001Lecanemab\u5df2\u88ab\u8b49\u5be6\u53ef\u6e05\u9664\u8166\u4e2d\u4e0d\u6b63\u5e38\u7684\u985e\u6fb1\u7c89\u86cb\u767d\u3002\u827e\u62c9\u502b\u7684ALN-APP\u6cbb\u7642\u5247\u66f4\u9032\u4e00\u6b65\uff0c\u85c9\u7531\u6e1b\u5c11\u9020\u6210\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u86cb\u767d\u8cea\uff0c\u5728\u4e00\u958b\u59cb\u963b\u6b62\u5176\u7522\u751f\u3002\u82f1\u570b\u5e36\u9818\u8a66\u9a57\u7684\u795e\u7d93\u75c5\u5b78\u8005\u51f1\u745f\u7433\u00b7\u7a46\u9ed8\u91cc(Catherine Mummery)\u7684\u91ab\u7642\u7814\u7a76\u767c\u73fe\u55ae\u4e00\u5291\u91cf\u7684ALN-APP\u300c\u57fa\u56e0\u975c\u9ed8\u300d(gene silencing)\u7642\u6cd5\u53ef\u5c07\u5371\u96aa\u7684\u6fb1\u7c89\u6a23\u86cb\u767d\u524d\u9a45\u86cb\u767d(Amyloid Precursor Protein)\u6c34\u5e73\u6e1b\u5c1190%\uff0c\u5728\u516d\u500b\u6708\u5f8c\u4ecd\u964d\u4f4e65%\u3002<\/p>\n\n\n\n<p>\u9019\u4e00\u7642\u6cd5\u4e0d\u662f\u6e05\u9664\u86cb\u767d\u8cea\uff0c\u800c\u662f\u4e00\u958b\u59cb\u5c31\u5f9e\u4e0a\u6e38\u963b\u6b62\u86cb\u767d\u8cea\u7522\u751f\u3002\u5982\u679c\u53ea\u662f\u6e05\u9664\u5df2\u7d93\u5b58\u5728\u7684\u86cb\u767d\u8cea\uff0c\u5c31\u5f97\u5728\u95a5\u9580\u4ecd\u6253\u958b\u7684\u60c5\u6cc1\u4e0b\u4e0d\u65b7\u6e05\u9664\u640d\u5bb3\uff0c\u4f46\u82e5\u662f\u95dc\u9589\u95a5\u9580\uff0c\u5c31\u6709\u66f4\u597d\u7684\u6a5f\u6703\u9632\u6b62\u9032\u4e00\u6b65\u7684\u50b7\u5bb3\u3002<\/p>\n\n\n\n<p>\u4e0a\u500b\u6708\u5728\u963f\u59c6\u65af\u7279\u4e39\u6703\u8b70\u767c\u8868\u7684\u7b2c\u4e00\u968e\u6bb5\u8a66\u9a57\u8868\u660e\u8a72\u7642\u6cd5\u5b89\u5168\uff0c\u4e14\u526f\u4f5c\u7528\u5f88\u8f15\u5fae\u3002\u76f4\u63a5\u5f9e\u4e0b\u80cc\u7684\u810a\u9ad3\u6ce8\u5c04\uff0c\u4e00\u5e74\u53ea\u9700\u8981\u65bd\u7528\u4e00\u6b21\u6216\u5169\u6b21\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%BD%B1%E9%9F%BF\"><\/span>\u5f71\u97ff<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%88%90%E6%9C%AC\"><\/span>\u6210\u672c<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u7531\u65bc\u85e5\u5546\u7684\u6295\u5165\u6210\u672c\u548c\u6642\u9593\u9a5a\u4eba\uff0c\u52a0\u4e0a\u958b\u767c\u7684\u56f0\u96e3\u5ea6\u592a\u9ad8\uff0c\u9020\u6210\u76ee\u524d\u5e02\u5834\u4e0a\u552f\u4e00\u7684\u9019\u4e09\u5927\u85e5\u54c1\u7684\u85e5\u50f9\u90fd\u5f88\u9ad8\u6602\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%89%AF%E4%BD%9C%E7%94%A8\"><\/span>\u526f\u4f5c\u7528<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4e0d\u53ea\u6210\u672c\uff0c\u4e09\u7a2e\u65b0\u85e5\u90fd\u6709\u5f88\u5371\u96aa\u7684\u526f\u4f5c\u7528\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B0%8D%E8%B3%87%E6%9C%AC%E5%B8%82%E5%A0%B4%E7%9A%84%E5%BD%B1%E9%9F%BF\"><\/span>\u5c0d\u8cc7\u672c\u5e02\u5834\u7684\u5f71\u97ff<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%9B%B8%E9%97%9C%E4%BC%81%E6%A5%AD%E7%9A%84%E8%82%A1%E5%83%B9%E8%A1%A8%E7%8F%BE\"><\/span>\u76f8\u95dc\u4f01\u696d\u7684\u80a1\u50f9\u8868\u73fe<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>\u7f8e\u80a1\u4ee3\u78bc<\/td><td>10\/16\/2023\u80a1\u50f9<\/td><td>\u904e\u53bb\u4e00\u5e74\u80a1\u50f9\u8868\u73fe<\/td><td>\u672c\u76ca\u6bd4<\/td><td>\u5e02\u503c(\u5341\u5104\u7f8e\u91d1)<\/td><td>\u6b96\u5229\u7387<\/td><\/tr><tr><td>LLY<\/td><td>617.57<\/td><td>85.46%<\/td><td>85.8<\/td><td>586.26<\/td><td>0.73%<\/td><\/tr><tr><td>BIIB<\/td><td>265.82<\/td><td>-1.38%<\/td><td>14.47<\/td><td>38.48<\/td><td>0.00%<\/td><\/tr><tr><td>ESAIY<\/td><td>13.9<\/td><td>-10.41%<\/td><td>47.95<\/td><td>16.92<\/td><td>0.00%<\/td><\/tr><tr><td>JNJ<\/td><td>157.9<\/td><td>-5.25%<\/td><td>32<\/td><td>380.23<\/td><td>3.01%<\/td><\/tr><tr><td>PFE<\/td><td>33.69<\/td><td>-22.82%<\/td><td>8.98<\/td><td>190.07<\/td><td>4.87%<\/td><\/tr><tr><td>NVS<\/td><td>96.74<\/td><td>32.30%<\/td><td>26.96<\/td><td>218.34<\/td><td>3.62%<\/td><\/tr><tr><td>ABBV<\/td><td>148.03<\/td><td>2.51%<\/td><td>30.45<\/td><td>261.28<\/td><td>4.00%<\/td><\/tr><tr><td>ALMN<\/td><td>166.91<\/td><td>-14.44%<\/td><td>0<\/td><td>20.86<\/td><td>0.00%<\/td><\/tr><tr><td>\u6a19\u666e500\u6307\u6578<\/td><td>4,371.98<\/td><td>18.87%<\/td><td>18.52<\/td><td>35,002<\/td><td>1.80%<\/td><\/tr><\/tbody><\/table><figcaption class=\"wp-element-caption\">(\u8cc7\u6599\u4f86\u6e90\uff1a\u8c37\u6b4c\u8ca1\u7d93\u548c\u96c5\u864e\u8ca1\u7d93)<\/figcaption><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%A6%AE%E4%BE%86\"><\/span>\u79ae\u4f86<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>2023\u5e745\u67083\u65e5\uff0c\u79ae\u4f86\u516c\u4f48Donanemab\u81e8\u5e8a\u6578\u64da\uff0c\u80a1\u50f9\u5927\u6f326.68%\uff0c\u5e02\u503c\u8d85\u904e4000\u5104\u7f8e\u91d1\uff0c\u6210\u70ba\u7d14\u85e5\u4f01\u9818\u57df\u7576\u4e4b\u7121\u6127\u7684\u4e00\u54e5\u3002\u5c0d\u65bc\u79ae\u4f86\u9019\u6a23\u7684\u8d85\u7d1a\u5de8\u982d\u4f86\u8aaa\uff0c\u5e02\u503c\u5c64\u9762\u51fa\u73fe\u5287\u70c8\u6ce2\u52d5\u4e26\u4e0d\u591a\u898b\u3002\u904e\u53bb3\u5e74\uff0c\u79ae\u4f86\u55ae\u65e5\u5e02\u503c\u6ce2\u52d5\u8d85\u904e5%\u7684\u6b21\u6578\u6975\u70ba\u7f55\u898b\uff0c\u800cDonanemab\u537b\u5f15\u767c\u4e86\u5176\u4e2d3\u6b21\u5de8\u9707\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%99%BE%E5%81%A5\"><\/span>\u767e\u5065<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u6b63\u5982\u6211\u5728\u300a<a href=\"https:\/\/www.books.com.tw\/products\/0010935641?sloc=main\" target=\"_blank\" rel=\"noreferrer noopener\">10\u500d\u80a1\u6cd5\u5247<\/a>\u300b\u4e00\u66f8\u4e2d\u6240\u63cf\u8ff0\u904e\u7684\uff0c\u963f\u8332\u6d77\u9ed8\u75c7\u662f\u552f\u4e00\u4eba\u985e\u5c1a\u5f85\u653b\u514b\u7684\u4e3b\u8981\u75be\u75c5\uff0c\u5e7e\u4e4e\u6240\u6709\u5927\u578b\u85e5\u5546\u90fd\u66fe\u5927\u8209\u6295\u5165\u8cc7\u6c34\u7814\u767c\uff0c\u4f46\u5927\u90e8\u4efd\u90fd\u7121\u529f\u800c\u8fd4\uff0c\u53ea\u5269\u4e0b\u7f85\u6c0f\uff08\u7f8e\u80a1\u4ee3\u78bc\uff1aRHHBY\uff09\u767e\u5065\u548c\u79ae\u4f86\u9019\u5169\u5927\u5927\u578b\u85e5\u5546\u6709\u660e\u9865\u7684\u9032\u5c55\u3002<\/p>\n\n\n\n<p>\u5c24\u5176\u767e\u5065\u4e00\u518d\u767c\u8868\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u591a\u7a2e\u85e5\u7269\uff0c\u904e\u53bb\u5e7e\u5e74\u516c\u53f8\u7684\u80a1\u50f9\u7684\u5927\u8d77\u5927\u843d\uff0c\u4e5f\u5e7e\u4e4e\u548c\u516c\u53f8\u963f\u8332\u6d77\u9ed8\u75c7\u7684\u85e5\u7269\u7684\u4e3b\u8981\u968e\u6bb5\u81e8\u5e8a\u7d50\u679c\u7684\u9032\u5c55\u800c\u5287\u70c8\u6ce2\u52d5\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%88%86%E5%B2%90%E7%9A%84%E5%81%A5%E4%BF%9D%E7%B5%A6%E4%BB%98\"><\/span>\u5206\u5c90\u7684\u5065\u4fdd\u7d66\u4ed8<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>\u67d0\u4e9b\u79c1\u4eba\u4fdd\u96aa\u516c\u53f8\u4e0d\u9858\u70ba\u60a3\u8005\u7d66\u4ed8\u7387\u5148\u7372\u51c6\u4e0a\u5e02\u7684\u963f\u8332\u6d77\u9ed8\u75c7\u65b0\u85e5\uff0c\u539f\u56e0\u5728\u65bc\u65b0\u85e5\u96d6\u7136\u662f\u5be6\u9a57\u85e5\u7269\uff0c\u4f46\u4e00\u5e74\u7528\u85e5\u50f9\u683c\u9ad8\u90542\u842c6000\u5143\u3002<\/p>\n\n\n\n<p>\u4fd7\u7a31\u7d05\u85cd\u5361\u7684\u806f\u90a6\u91ab\u7642\u4fdd\u96aa(Medicare)\u5247\u70ba\u7d55\u5927\u591a\u6578\u75c5\u60a3\u63d0\u4f9bLeqembi\u7d66\u4ed8\u3002<\/p>\n\n\n\n<p>\u62d2\u7d55\u70baLeqembi\u63d0\u4f9b\u7d66\u4ed8\u7684\u4fdd\u96aa\u696d\u8005\u5305\u62ec\u5728\u7d10\u7d04\u5dde\u3001\u8cd3\u5dde\u3001\u5fb7\u62c9\u74e6\u5dde\u3001\u897f\u7dad\u5409\u5c3c\u4e9e\u5dde\u63a8\u51fa\u85cd\u5341\u5b57\u85cd\u76fe\u4fdd\u96aa(BCBS)\u7684Highmark\u4fdd\u96aa\u516c\u53f8\u3001\u5317\u5361\u7f85\u4f86\u7d0d\u5dde\u85cd\u5341\u5b57\u85cd\u76fe\u4fdd\u96aa\u3001\u8cd3\u5dde\u5730\u5340\u7684\u7368\u7acb\u85cd\u5341\u5b57\u4fdd\u96aa(Independence BC)\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"160\" height=\"128\" src=\"https:\/\/www.granitefirm.com\/blog\/wp-content\/uploads\/2023\/08\/az-1600x1200-1.jpg\" alt=\"\u963f\u8332\u6d77\u9ed8\" class=\"wp-image-38227\"\/><figcaption class=\"wp-element-caption\">credit: Wiki<\/figcaption><\/figure>\n\n\n\n<p><em>\u672c\u4eba\u70ba\u539f\u6587\u4f5c\u8005\uff0c\u672c\u6587\u7cbe\u83ef\u7248\u539f\u520a\u767b\u5728Smart\u667a\u5bcc\u6708\u520b<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%9B%B8%E9%97%9C%E6%96%87%E7%AB%A0\"><\/span>\u76f8\u95dc\u6587\u7ae0<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2025\/10\/18\/%e4%b8%ad%e5%9c%8b%e7%9a%84%e7%94%9f%e6%8a%80%e8%a3%bd%e8%97%a5%e6%a5%ad%e9%96%8b%e5%a7%8b%e5%b1%95%e7%8f%be%e5%ae%83%e7%9a%84%e6%b7%b1%e5%ba%a6%e6%b1%82%e7%b4%a2%e6%99%82%e5%88%bb\/\">\u4e2d\u570b\u7684\u751f\u6280\u88fd\u85e5\u696d\u958b\u59cb\u5c55\u73fe\u5b83\u7684\u6df1\u5ea6\u6c42\u7d22\u6642\u523b<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2025\/09\/16\/%e5%ba%b7%e6%96%b9%e8%82%ba%e7%99%8c%e8%97%a5%e6%96%b0%e8%97%a5%e7%99%82%e6%95%88%e5%a4%a7%e5%8b%9d%e5%85%a8%e7%90%83%e8%97%a5%e6%a6%9c%e9%8a%b7%e9%87%8f%e5%86%a0%e8%bb%8d\/\">\u5eb7\u65b9\uff08Akeso\u00a0\uff09\u80ba\u764c\u85e5\u65b0\u85e5\u7642\u6548\u5927\u52dd\u5168\u7403\u85e5\u699c\u92b7\u91cf\u51a0\u8ecd\uff0c\u9707\u64bc\u7684\u751f\u6280\u696dDeepSeek\u4e8b\u4ef6<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/11\/02\/%e5%9f%ba%e5%9b%a0%e7%b7%a8%e8%bc%afcasgevy%e8%a2%ab%e6%89%b9%e5%87%86\/\">\u5168\u7403\u9996\u500b\u57fa\u56e0\u7de8\u8f2f\u7642\u6cd5Casgevy\u7d42\u65bc\u88ab\u6279\u51c6\u4e0a\u5e02<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/11\/17\/%E5%9F%BA%E5%9B%A0%E7%B7%A8%E8%BC%AF%E7%99%82%E6%B3%95%E5%89%B5%E5%A7%8B%E8%80%85crispr%E5%A6%82%E4%BD%95%E8%B3%BA%E9%8C%A2%EF%BC%9F\/\">\u57fa\u56e0\u7de8\u8f2f\u7642\u6cd5\u5275\u59cb\u8005CRISPR\u5982\u4f55\u8cfa\u9322\uff1f<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%E9%98%BF%E8%8C%B2%E6%B5%B7%E9%BB%98%E7%97%87%EF%BC%8C%E5%94%AF%E4%B8%80%E5%B0%9A%E5%BE%85%E6%94%BB%E5%85%8B%E7%9A%84%E4%B8%BB%E8%A6%81%E7%96%BE%E7%97%85%E7%9A%84%E7%9B%AE%E5%89%8D%E9%80%B2%E5%B1%95\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u963f\u8332\u6d77\u9ed8\u75c7\uff0c\u552f\u4e00\u5c1a\u5f85\u653b\u514b\u7684\u4e3b\u8981\u75be\u75c5\u7684\u76ee\u524d\u9032\u5c55\u548c\u76f8\u95dc\u4f01\u696d<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/28\/%e6%8a%97%e7%97%85%e6%af%92%e8%97%a5%e7%8e%8b%e5%90%89%e5%88%a9%e5%be%b7%e9%96%8b%e7%99%bc%e5%87%ba%e4%b8%96%e4%b8%8a%e9%a6%96%e6%94%af%e6%84%9b%e6%bb%8b%e7%96%ab%e8%8b%97\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u6297\u75c5\u6bd2\u85e5\u738b\u5409\u5229\u5fb7\uff08Gilead\uff09\u958b\u767c\u51fa\u4e16\u4e0a\u9996\u652f\u611b\u6ecb\u75ab\u82d7<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/06\/%e5%90%8c%e6%99%82%e6%8f%a1%e6%9c%89%e5%85%a9%e5%a4%a7%e6%9c%aa%e4%be%86%e6%98%8e%e6%98%9f%e6%96%b0%e8%97%a5%e7%9a%84%e7%b6%ad%e4%ba%acviking\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u540c\u6642\u63e1\u6709\u5169\u5927\u672a\u4f86\u660e\u661f\u65b0\u85e5\u7684\u7dad\u4eac\uff08Viking\uff09<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%E9%9D%9E%E9%85%92%E7%B2%BE%E6%80%A7%E8%84%82%E8%82%AA%E8%82%9D%E7%82%8Emash\/#google_vignette\" target=\"_blank\" rel=\"noreferrer noopener\">FDA\u9996\u6b21\u6279\u51c6\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u708e(MASH)\u6cbb\u7642\u85e5\u7269<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/11\/15\/%e7%a6%ae%e4%be%86%e7%82%ba%e4%bd%95%e8%83%bd%e6%88%90%e7%82%ba%e6%96%b0%e4%b8%80%e4%bb%a3%e7%9a%84%e5%85%a8%e7%90%83%e8%a3%bd%e8%97%a5%e5%b8%82%e5%80%bc%e7%8e%8b%ef%bc%9f\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u79ae\u4f86\uff08Eli Lilly\uff09\u70ba\u4f55\u80fd\u6210\u70ba\u65b0\u4e00\u4ee3\u7684\u5168\u7403\u88fd\u85e5\u5e02\u503c\u738b\uff1f<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2022\/02\/23\/%e6%95%a3%e6%ad%a5%e6%9c%89%e5%8a%a9%e6%96%bc%e6%80%9d%e8%80%83\/\">\u6563\u6b65\u6709\u52a9\u65bc\u601d\u8003<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/08\/09\/%e4%bc%b0%e5%80%bc%e9%a9%9a%e4%ba%ba%e7%9a%84%e5%a4%a7%e8%97%a5%e5%bb%a0%e7%a6%ae%e4%be%86\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u6700\u65b0\u5e02\u503c\u5168\u7403\u7b2c\u4e00\u4f30\u503c\u9a5a\u4eba\u7684\u5927\u85e5\u5ee0\u79ae\u4f86\uff08Eli Lilly\uff09<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2022\/10\/17\/%e5%85%a8%e7%be%8e%e6%9c%80%e5%a4%a7%e7%9a%84%e5%81%a5%e4%bf%9d%e9%9b%86%e5%9c%98%e8%81%af%e5%90%88%e5%81%a5%e5%ba%b7%e4%bf%9d%e9%9a%aa\/\">\u5168\u7403\u6700\u5927\u7684\u5065\u4fdd\u5546\u806f\u5408\u5065\u5eb7\u4fdd\u96aa\uff0c\u9053\u74ca\u7684\u512a\u7b49\u751f<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a 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href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/05\/17\/%e7%be%85%e6%b0%8f%e6%8a%97%e7%99%8c%e8%97%a5%e7%a5%9e\/\">\u7f85\u6c0f\u88fd\u85e5\uff08Roche\uff09\uff0c\u6297\u764c\u85e5\u795e<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/?s=%E5%85%A8%E7%90%83%E7%AC%AC%E4%B8%80%E5%A4%A7%E8%97%A5%E5%BB%A0%E8%BC%9D\" target=\"_blank\" rel=\"noreferrer noopener\">\u5168\u7403\u7b2c\u4e00\u5927\u85e5\u5ee0\u8f1d\u745e\uff08Pfizer<\/a>\uff09\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/08\/09\/%e4%bc%b0%e5%80%bc%e9%a9%9a%e4%ba%ba%e7%9a%84%e5%a4%a7%e8%97%a5%e5%bb%a0%e7%a6%ae%e4%be%86\/\">\u4f30\u503c\u9a5a\u4eba\u7684\u5927\u85e5\u5ee0\u79ae\u4f86\uff08Eli Lilly\uff09<\/a>\u300b<\/li>\n<\/ul>\n\n\n\n<p><em><strong>\u91cd\u8981\u8072\u660e<\/strong><\/em><\/p>\n\n\n\n<ul 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