{"id":45502,"date":"2024-06-02T23:56:00","date_gmt":"2024-06-02T15:56:00","guid":{"rendered":"https:\/\/www.granitefirm.com\/blog\/?p=45502"},"modified":"2025-11-07T11:13:20","modified_gmt":"2025-11-07T03:13:20","slug":"%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash","status":"publish","type":"post","link":"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/","title":{"rendered":"FDA\u9996\u6b21\u6279\u51c6\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u708e(MASH)\u6cbb\u7642\u85e5\u7269"},"content":{"rendered":"\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_88 counter-hierarchy ez-toc-counter ez-toc-custom ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"\u986f\u793a\/\u96b1\u85cf\u5167\u5bb9\u76ee\u9304\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #ffffff;color:#ffffff\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #ffffff;color:#ffffff\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/#%E8%84%82%E8%82%AA%E6%80%A7%E8%82%9D%E7%82%8E%EF%BC%88MASH%EF%BC%89\" >\u8102\u80aa\u6027\u809d\u708e\uff08MASH\uff09<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/#%E7%B0%A1%E4%BB%8B\" >\u7c21\u4ecb<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/#%E6%9C%89%E5%A4%9A%E5%B0%91%E6%82%A3%E8%80%85%EF%BC%9F\" >\u6709\u591a\u5c11\u60a3\u8005\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/#%E5%B8%82%E5%A0%B4%E6%9C%89%E5%A4%9A%E5%A4%A7%EF%BC%9F\" >\u5e02\u5834\u6709\u591a\u5927\uff1f<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/#%E6%9C%AA%E4%BE%86%E8%97%A5%E6%A5%AD%E7%9A%84%E6%96%B0%E8%97%8D%E6%B5%B7\" >\u672a\u4f86\u85e5\u696d\u7684\u65b0\u85cd\u6d77<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/#%E5%9B%B0%E9%9B%A3%E4%B9%8B%E8%99%95\" >\u56f0\u96e3\u4e4b\u8655<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/#FDA%E5%89%9B%E6%A0%B8%E5%87%86%E7%AC%AC%E4%B8%80%E6%AC%BEMASH%E6%96%B0%E8%97%A5\" >FDA\u525b\u6838\u51c6\u7b2c\u4e00\u6b3eMASH\u65b0\u85e5<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/#%E7%9B%AE%E5%89%8D%E7%9F%A5%E5%90%8D%E7%9A%84%E5%B9%BE%E7%A8%AE%E8%97%A5%E7%89%A9\" >\u76ee\u524d\u77e5\u540d\u7684\u5e7e\u7a2e\u85e5\u7269<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/#%E6%B8%9B%E9%87%8D%E8%97%A5%E7%89%A9%E7%9A%84%E6%96%B0%E9%81%A9%E6%87%89%E7%97%87\" >\u6e1b\u91cd\u85e5\u7269\u7684\u65b0\u9069\u61c9\u75c7<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/#Zealand%E7%9A%84survodutide\" >Zealand\u7684survodutide<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/#%E8%AB%BE%E5%92%8C%E8%AB%BE%E5%BE%B7%E7%9A%84%E5%8F%B8%E7%BE%8E%E6%A0%BC%E9%AD%AF%E8%82%BD\" >\u8afe\u548c\u8afe\u5fb7\u7684\u53f8\u7f8e\u683c\u9b6f\u80bd<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/#%E7%A6%AE%E4%BE%86%E7%9A%84Mounjaro\" >\u79ae\u4f86\u7684Mounjaro<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/#%E9%9D%9E%E6%B8%9B%E9%87%8D%E8%97%A5%E6%96%B0%E9%81%A9%E6%87%89%E7%97%87%E5%BB%A0%E5%95%86\" >\u975e\u6e1b\u91cd\u85e5\u65b0\u9069\u61c9\u75c7\u5ee0\u5546<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/#Akero%E7%9A%84Efruxifermin\" >Akero\u7684Efruxifermin<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/#Inventiva%E7%9A%84Lanifibranor\" >Inventiva\u7684Lanifibranor<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/#Sagimet%E7%9A%84Denifanstat\" >Sagimet\u7684Denifanstat<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/#Madrigal%E7%9A%84Resmetirom\" >Madrigal\u7684Resmetirom<\/a><ul class='ez-toc-list-level-5' ><li class='ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/#%E5%B8%82%E5%A0%B4%E7%9A%84%E9%A0%98%E5%85%88%E8%80%85\" >\u5e02\u5834\u7684\u9818\u5148\u8005<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-5'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/#%E5%B7%B2%E8%A2%AB%E6%A0%B8%E6%B7%AE\" >\u5df2\u88ab\u6838\u6dee<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/#Viking%E7%9A%84VK2809\" >Viking\u7684VK2809<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%e9%9d%9e%e9%85%92%e7%b2%be%e6%80%a7%e8%84%82%e8%82%aa%e8%82%9d%e7%82%8emash\/#%E7%9B%B8%E9%97%9C%E6%96%87%E7%AB%A0\" >\u76f8\u95dc\u6587\u7ae0<\/a><\/li><\/ul><\/nav><\/div>\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%84%82%E8%82%AA%E6%80%A7%E8%82%9D%E7%82%8E%EF%BC%88MASH%EF%BC%89\"><\/span>\u8102\u80aa\u6027\u809d\u708e\uff08<strong>MASH<\/strong>\uff09<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%B0%A1%E4%BB%8B\"><\/span>\u7c21\u4ecb<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><a href=\"https:\/\/en.wikipedia.org\/wiki\/Metabolic_dysfunction%E2%80%93associated_steatotic_liver_disease\" target=\"_blank\" rel=\"noreferrer noopener\">\u4ee3\u8b1d\u529f\u80fd\u969c\u7919\u76f8\u95dc\u7684\u8102\u80aa\u809d\u75c5(MASLD)\u662f2023\u5e74\u91dd\u5c0d\u4ee5\u524d\u7a31\u70ba\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u75c5(NAFLD)\u7684\u75be\u75c5\u6240\u63a1\u7528\u7684\u540d\u7a31<\/a>\u3002\u7576\u809d\u81df\u4e2d\u8102\u80aa\u5806\u7a4d\u904e\u591a\uff08\u809d\u8102\u80aa\u8b8a\u6027\uff09\u4e26\u4e14\u81f3\u5c11\u5b58\u5728\u4e00\u7a2e\u4ee3\u8b1d\u5371\u96aa\u56e0\u5b50\u6642\uff0c\u5373\u53ef\u8a3a\u65b7\u51fa\u9019\u7a2e\u60c5\u6cc1\u3002\u7576\u9069\u5ea6\u98f2\u9152\u4e5f\u5b58\u5728\u6642\uff0c\u4f7f\u7528\u8853\u8a9eMetALD\uff0c\u7576\u9152\u7cbe\u6027\u809d\u75c5(ALD)\u662f\u8102\u80aa\u8b8a\u6027\u809d\u75c5\u7684\u552f\u4e00\u539f\u56e0\u6642\uff0c\u5c07\u5176\u8207\u9152\u7cbe\u6027\u809d\u75c5(ALD)\u5340\u5206\u958b\u4f86\u3002NAFL\uff08non-alcoholic fatty liver\uff09\u548cMASH\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08\u4ee5\u524d\u7a31\u70baNASH\uff0cnon-alcoholic steatohepatitis\uff09\u4e00\u8a5e\u5df2\u88ab\u7528\u4f86\u63cf\u8ff0\u4e0d\u540c\u7684\u56b4\u91cd\u7a0b\u5ea6\uff0c\u5f8c\u8005\u8868\u660e\u5b58\u5728\u9032\u4e00\u6b65\u7684\u809d\u81df\u767c\u708e\u3002NAFL\u6bd4NASH\u5371\u96aa\u6027\u5c0f\uff0c\u901a\u5e38\u4e0d\u6703\u9032\u5c55\u70baNASH\uff0c\u4f46\u9019\u7a2e\u9032\u5c55\u6700\u7d42\u53ef\u80fd\u5c0e\u81f4\u4f75\u767c\u75c7\uff0c\u5982\u809d\u786c\u5316\u3001\u809d\u764c\u3001\u809d\u8870\u7aed\u548c\u5fc3\u8840\u7ba1\u75be\u75c5\u3002\u901a\u5e38\u662f\u7531\u8207\u98f2\u98df\u6709\u95dc\u7684\u809d\u81df\u8102\u80aa\u5806\u7a4d\u6240\u5f15\u8d77\u7684\uff0c\u5c0e\u81f4\u708e\u75c7\uff0c\u96a8\u5f8c\u53ef\u80fd\u5c0e\u81f4\u809d\u786c\u5316\uff1b\u6709\u4e9b\u60a3\u8005\u751a\u81f3\u9700\u8981\u9032\u884c\u5668\u5b98\u7684\u79fb\u690d\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%9C%89%E5%A4%9A%E5%B0%91%E6%82%A3%E8%80%85%EF%BC%9F\"><\/span>\u6709\u591a\u5c11\u60a3\u8005\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u6839\u64daFrost&amp;Sullivan\u7684\u4f30\u8a08\uff0c\u76ee\u524dMASH\u809d\u708e\u60a3\u8005\u5728\u5168\u7403\u4f30\u8a08\u67091.15\u5104\u4eba\uff0c2030\u5e74\u5168\u7403\u53ca\u4e2d\u570b\u7684MASH\u60a3\u75c5\u2f08\u6578\u5206\u5225\u90544.86\u5104\u2f08\u30010.56\u5104\u2f08\uff0c\u4e3b\u8981\u7528\u6236\u5728\u7f8e\u570b\u3001\u897f\u6b50\u548c\u65e5\u672c\u3002\u5c08\u696d\u7814\u7a76\u986f\u793a\uff0c12%\u7f8e\u570b\u4eba\u548c6%\u6b50\u6d32\u4eba\u5df2\u70ba\u6b64\u75c5\u6240\u82e6\u3002<\/p>\n\n\n\n<p>\u99ac\u5fb7\u91cc\u52a0\u723e\uff08Madrigal\uff09\u9810\u8a08\u6709 150 \u842c\u7f8e\u570b\u4eba\u88ab\u8a3a\u65b7\u51fa\u60a3\u6709MASH\uff0c\u5176\u4e2d\u80a5\u80d6\u548c\u7cd6\u5c3f\u75c5\u662f\u5c0e\u81f4\u75be\u75c5\u6d41\u884c\u7684\u56e0\u7d20\u4e4b\u4e00\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B8%82%E5%A0%B4%E6%9C%89%E5%A4%9A%E5%A4%A7%EF%BC%9F\"><\/span>\u5e02\u5834\u6709\u591a\u5927\uff1f<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u6839\u64daFrost&amp;Sullivan\u7684\u9810\u6e2c\uff0c\u52302025 \u5e74\u6cbb\u7642MASH\u85e5\u7269\u7684\u5e02\u5834\u5bb9\u91cf\u5c07\u8d85\u904e100\u5104\u7f8e\u5143\uff0c\u5176\u4e2d2016\u81f32025\u5e74\u8907\u5408\u6210\u9577\u7387\u53ef\u905420.19%\u3002<\/p>\n\n\n\n<p>\u53e6\u64da\u7814\u7a76\u96c6\u5718GlobalData\u7684\u4f30\u8a08\uff0cMASH\u52302026\u5e74\u6703\u6210\u70ba\u50f9\u503c\u8d85\u904e250\u5104\u7f8e\u5143\u7684\u5e02\u5834\u3002\u800c\u4e14\uff0c\u9019\u5e02\u5834\u5f9e\u5927\u85e5\u5ee0\u63a8\u51fa\u5c0d\u6cbb\u7684\u85e5\u65b9\u958b\u59cb\uff0c\u5c31\u6703\u6bcf\u5e74\u6210\u957745%\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%9C%AA%E4%BE%86%E8%97%A5%E6%A5%AD%E7%9A%84%E6%96%B0%E8%97%8D%E6%B5%B7\"><\/span>\u672a\u4f86\u85e5\u696d\u7684\u65b0\u85cd\u6d77<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u60a3\u8005\u6578\u91cf\u9f90\u2f24\uff0c\u6cbb\u7642\u85e5\u7269\u537b\u76f8\u7576\u7a00\u7f3a\u3002\u5982\u6b64\u8a98\u2f08\u7684\u5e02\u5834\uff0c\u5438\u5f15\u4e86\u5409\u5229\u5fb7\u3001\u8afe\u83ef\u3001\u9ed8\u6c99\u6771\u7b49\u88fd\u864a\u5de8\u982d\u7684\u4f48\u5c40\uff0c\u53ef\u60dc\u90fd\u7121\u529f\u800c\u8fd4\u3002\u2f6c\u524d\u5168\u7403\u5728\u7814\u767c\u4e2d\u7684MASH\u85e5\u7269\u5df2\u6709\u6578\u767e\u7a2e\uff0c\u6a19\u9776THR-\u03b2\u3001FGF21\u3001PPAR\u548cGLP-1\u7b49\u8fd120\u7a2e\u6a19\u9776\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%9B%B0%E9%9B%A3%E4%B9%8B%E8%99%95\"><\/span>\u56f0\u96e3\u4e4b\u8655<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>MASH\u6cbb\u7642\u85e5\u7269\u4e4b\u6240\u4ee5\u7a00\u7f3a\uff0c\u9664MASH\u767c\u75c5\u6a5f\u5236\u8907\u96dc\u5916\uff0c\u9084\u5728\u65bcFDA\u56b4\u683c\u7684\u81e8\u5e8a\u7d42\u9ede\u8a8d\u5b9a\uff1a\u9700\u8981\u809d\u7a7f\u523a\u7684\u75c5\u7406\u5b78\u8a55\u50f9\uff0c\u5f71\u50cf\u5b78\u8a55\u50f9\u3001\u2f8e\u6e05\u5b78\u8a55\u50f9\u5747\u4e0d\u80fd\u4f5c\u70ba\u4e0a\u5e02\u5be9\u6279\u7684\u4e3b\u8981\u7d42\u9ede\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"FDA%E5%89%9B%E6%A0%B8%E5%87%86%E7%AC%AC%E4%B8%80%E6%AC%BEMASH%E6%96%B0%E8%97%A5\"><\/span>FDA\u525b\u6838\u51c6\u7b2c\u4e00\u6b3eMASH\u65b0\u85e5<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u5176\u4e2d\u99ac\u5fb7\u91cc\u52a0\u723e\uff08Madrigal\uff09\u7684Resmetirom\uff0c\u7531\u65bc\u5df2\u9032\u884c\u4e09\u671f\u5be6\u9a57\uff0cFDA\u5df2\u57282024\u5e743\u670814\u65e5\u6838\u6dee\uff0c\u6210\u70ba\u53f2\u4e0a\u6700\u5148\u88ab\u76e3\u7ba1\u6279\u51c6\u7684MASH\u809d\u708e\u65b0\u85e5\uff08\u8a73\u898b\u4e0b\u6587\uff09\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%9B%AE%E5%89%8D%E7%9F%A5%E5%90%8D%E7%9A%84%E5%B9%BE%E7%A8%AE%E8%97%A5%E7%89%A9\"><\/span>\u76ee\u524d\u77e5\u540d\u7684\u5e7e\u7a2e\u85e5\u7269<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E6%B8%9B%E9%87%8D%E8%97%A5%E7%89%A9%E7%9A%84%E6%96%B0%E9%81%A9%E6%87%89%E7%97%87\"><\/span>\u6e1b\u91cd\u85e5\u7269\u7684\u65b0\u9069\u61c9\u75c7<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>\u5148\u524d\u5df2\u6709\u591a\u7a2e\u6e1b\u80a5\u85e5\u5927\u706b\u4ee4\u5ee0\u5546\u80a1\u50f9\u98c6\u5347\uff0c\u5305\u62ec\u79ae\u4f86\uff08\u7f8e\u80a1\u4ee3\u78bc\uff1aLLY\uff09\u548c\u540c\u6a23\u4f86\u81ea\u4e39\u9ea5\u7684\u8afe\u548c\u8afe\u5fb7\uff08\u7f8e\u80a1\u4ee3\u78bc\uff1aNOVO\uff09\u5c31\u56e0\u958b\u767c\u51fa\u6e1b\u80a5\u85e5Ozempic\u548cWegovy\u800c\u6210\u70ba\u6b50\u6d32\u5e02\u503c\u6700\u9ad8\u7684\u516c\u53f8\u3002\u9019\u4e00\u90e8\u4efd\uff0c\u8acb\u60a8\u53c3\u898b\u6211\u4e4b\u524d\u7684\u5e7e\u7bc7\u8cbc\u6587\u7684\u8a73\u7d30\u8a0e\u8ad6\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/11\/15\/%e7%a6%ae%e4%be%86%e7%82%ba%e4%bd%95%e8%83%bd%e6%88%90%e7%82%ba%e6%96%b0%e4%b8%80%e4%bb%a3%e7%9a%84%e5%85%a8%e7%90%83%e8%a3%bd%e8%97%a5%e5%b8%82%e5%80%bc%e7%8e%8b%ef%bc%9f\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u79ae\u4f86\uff08Eli Lilly\uff09\u70ba\u4f55\u80fd\u6210\u70ba\u65b0\u4e00\u4ee3\u7684\u5168\u7403\u88fd\u85e5\u5e02\u503c\u738b\uff1f<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/03\/30\/%e8%ab%be%e5%92%8c%e8%ab%be%e5%be%b7%e5%8f%b8%e7%be%8e%e6%a0%bc%e9%ad%af%e8%82%bd%e5%92%8c%e8%85%b8%e6%b3%8c%e7%b4%a0%e7%9a%84%e6%b8%9b%e9%87%8d%e6%95%88%e6%9e%9c\/\">\u8afe\u548c\u8afe\u5fb7\uff08Novo Nordisk\uff09\u7cd6\u5c3f\u75c5\u7684\u65b0\u85e5Semaglutide\uff08\u53f8\u7f8e\u683c\u9b6f\u80bd\uff09\u8afe\u548c\u6cf0 Ozempic\uff0cWegovy\u548cMounjaro\u88ab\u767c\u73fe\u5177\u6709\u9a5a\u4eba\u7684\u6e1b\u91cd\u6548\u679c<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/08\/09\/%e4%bc%b0%e5%80%bc%e9%a9%9a%e4%ba%ba%e7%9a%84%e5%a4%a7%e8%97%a5%e5%bb%a0%e7%a6%ae%e4%be%86\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u6700\u65b0\u5e02\u503c\u5168\u7403\u7b2c\u4e00\u4f30\u503c\u9a5a\u4eba\u7684\u5927\u85e5\u5ee0\u79ae\u4f86\uff08Eli Lilly\uff09<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/08\/07\/%e6%b8%9b%e9%87%8d%e8%97%8d%e6%b5%b7%e6%98%af%e8%97%a5%e5%93%81%e5%b8%82%e5%a0%b4%e6%9c%aa%e4%be%86%e7%9a%84%e9%87%91%e9%9b%9e%e6%af%8d\/\">\u6e1b\u91cd\u85cd\u6d77\u662f\u85e5\u54c1\u5e02\u5834\u672a\u4f86\u7684\u91d1\u96de\u6bcd<\/a>\u300b<\/li>\n<\/ul>\n\n\n\n<p>\u6e1b\u80a5\u85e5\u5e02\u5834\u7684\u84ec\u52c3\u767c\u5c55\u8b93\u591a\u5bb6\u85e5\u5ee0\u8cfa\u5f97\u76c6\u6eff\u7f3d\u6eff\uff0c\u4ee5\u4e0b\u7684\u5e7e\u5bb6\u85e5\u5546\u5df2\u5c07\u6cbb\u7642MASH\u809d\u708e\u4f5c\u70ba\u5176\u65b0\u578b\u6e1b\u91cd\u85e5\u7269\u7684\u65b0\u9069\u61c9\u75c7\u3002\u91cd\u8981\u7684\u662f\uff0c\u9019\u4e9b\u6e1b\u91cd\u85e5\u63a1\u7528\u7684\u90fd\u662fGLP-1\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Zealand%E7%9A%84survodutide\"><\/span>Zealand\u7684survodutide<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u4e39\u9ea5\u85e5\u5ee0Zealand Pharm\uff08\u7f8e\u80a1\u4ee3\u78bc\uff1aZLDPF\uff09\u4e5f\u4e0d\u7518\u843d\u5f8c\uff0c\u8a72\u516c\u53f82024\u5e742\u670826\u65e5\u516c\u4f48\u4e00\u9805\u8a66\u9a57\u7d50\u679c\u986f\u793a\uff0c\u65d7\u4e0b\u4e00\u6b3e\u809d\u75c5\u6cbb\u7642\u85e5\u7269\u6548\u679c\u826f\u597d\uff0c\u523a\u6fc0\u8a72\u516c\u53f8\u80a1\u50f92024\u5e742\u670826\u65e5\u55ae\u65e5\u98c6\u534736%\u3002<\/p>\n\n\n\n<p>Zealand Pharma\u53ca\u5fb7\u570b\u7684\u5408\u4f5c\u5546\u52c3\u6797\u683c\u6bb7\u683c\u7ff0\uff08Boehringer Ingelheim\uff0c\u672a\u4e0a\u5e02\uff09\u57282024\u5e742\u670826\u65e5\u7684\u4e00\u4efd\u516c\u544a\u4e2d\u8868\u793a\uff0c\u8a72\u516c\u53f8\u65d7\u4e0bsurvodutide\u85e5\u7269\u7684\u4e8c\u671f\u8a66\u9a57\u986f\u793a\uff0c83%\u7684\u6210\u5e74\u53d7\u8a66\u8005\u5c0d\u8a72\u85e5\u7269\u6cbb\u7642\u4ee3\u8b1d\u529f\u80fd\u969c\u7919\u76f8\u95dc\u8102\u80aa\u6027\u809d\u708e\uff08MASH\uff09\u7684\u6548\u679c\u8868\u73fe\u7a4d\u6975\u3002<\/p>\n\n\n\n<p>\u516c\u53f8\u5e0c\u671b\u5e0c\u671b\u8a72\u85e5\u57282027\u5e74\u62162028\u5e74\u63a8\u51fa\uff0c\u9019\u53d6\u6c7a\u65bc\u4e09\u671f\u8a66\u9a57\u7d50\u679c\u662f\u5426\u6709\u5229\u3002\u5206\u6790\u5e2b\u8868\u793a\uff0c\u8a66\u9a57\u7d50\u679c\u986f\u793a\u8a72\u85e5\u7684\u300c\u660e\u78ba\u52dd\u5229\u300d\u3002\u521d\u6b65\u7d50\u679c\u986f\u793a\uff0c\u5728\u8a66\u9a57\u4e2d\u4f7f\u7528\u7684\u5404\u7a2e\u5291\u91cf\u7684survodutide\u85e5\u7269\uff0c\u6cbb\u7642MASH\u809d\u708e\u5747\u7372\u5f97\u6210\u6548\uff0c\u800c\u4e14\u4f7f\u7528survodutide\u6cbb\u7642\u6c92\u6709\u986f\u793a\u51fa\u610f\u5916\u7684\u5b89\u5168\u6027\u6216\u8010\u53d7\u6027\u554f\u984c\uff0c\u5305\u62ec\u5728\u8f03\u9ad8\u5291\u91cf6.0\u6beb\u514b\u3002<\/p>\n\n\n\n<p>survodutide\u85e5\u7269\u662f\u900f\u904e\u6a21\u4effGLP-1\uff08\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u52dd\u80bd-1\uff09\u8178\u9053\u6fc0\u7d20\u6291\u5236\u98df\u617e\uff0c\u5c31\u50cf\u5176\u4ed6\u6ce8\u5c04\u985e\u6e1b\u80a5\u85e5\u4e00\u6a23\uff0c\u4f46\u8a72\u85e5\u4e5f\u6a21\u4eff\u4e86\u53e6\u4e00\u7a2e\u7a31\u70ba\u80f0\u9ad8\u8840\u7cd6\u7d20\u7684\u8178\u9053\u6fc0\u7d20\u3002Survodutide\u4e5f\u5c6c\u65bcGLP-1\uff08\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u52dd\u80bd-1\uff09\u985e\u85e5\u7269\uff0c\u985e\u4f3c\u8afe\u548c\u8afe\u5fb7\u7684Wegovy\u3002<\/p>\n\n\n\n<p>\u76ee\u524d\u6b63\u5728\u9032\u884c\u4e94\u9805\u91dd\u5c0d\u8d85\u91cd\u6216\u80a5\u80d6\u4eba\u7fa4\u7684\u4e09\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u76ee\u524d\u8a72\u85e5\u5df2\u7372\u5f97\u7f8e\u570b\u98df\u54c1\u548c\u85e5\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u6307\u5b9a\u70ba\u7684\u5feb\u901f\u901a\u9053\u7814\u767c\u85e5\u7269\u3002\u8a66\u9a57\u7d50\u679c\u8868\u660e\uff0c\u5373\u4f7f\u4f7f\u7528\u4e86\u6700\u9ad8\u5291\u91cf\uff0c\u8a72\u85e5\u7269\u4e5f\u662f\u5b89\u5168\u7684\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E8%AB%BE%E5%92%8C%E8%AB%BE%E5%BE%B7%E7%9A%84%E5%8F%B8%E7%BE%8E%E6%A0%BC%E9%AD%AF%E8%82%BD\"><\/span>\u8afe\u548c\u8afe\u5fb7\u7684\u53f8\u7f8e\u683c\u9b6f\u80bd<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u8afe\u548c\u8afe\u5fb7\u6b63\u5728\u5c0d\u5176Wegovy\u6e1b\u91cd\u6ce8\u5c04\u7684\u6d3b\u6027\u6210\u5206\u53f8\u7f8e\u683c\u9b6f\u80bd\uff08semaglutide\uff09\u9032\u884c\u91dd\u5c0dMASH\u809d\u708e\u7684\u7b2c\u4e09\u671f\u8a66\u9a57\uff0c\u9810\u8a082028\u5e74\u53ef\u63ed\u66c9\u7d50\u679c\u3002<\/p>\n\n\n\n<p>\u6839\u64da\u8afe\u548c\u8afe\u5fb7\u516c\u544a\uff0c\u53f8\u7f8e\u683c\u9b6f\u80bd\u5728\u6cbb\u7642MASH\u76842\u671f\u81e8\u5e8a\u4e2d\u7d50\u679c\u7a4d\u6975\uff0c\u5728\u63a5\u53d7\u6700\u9ad8\u5291\u91cf\u53f8\u7f8e\u683c\u9b6f\u80bd\u6cbb\u7642\u7d44\u7684\u60a3\u8005\u4e2d\uff0c66.7%\u60a3\u8005\u7684MASH\u75c7\u72c0\u5f97\u5230\u6d88\u9664\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%A6%AE%E4%BE%86%E7%9A%84Mounjaro\"><\/span>\u79ae\u4f86\u7684Mounjaro<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u79ae\u4f86\u63a8\u51fa\u7684\u6e1b\u91cd\u85e5\u7269Mounjaro\uff08\u4e5f\u7a31\u70baZepbound\uff09\uff0c\u4e5f\u6b63\u5728\u91dd\u5c0dMASH\u809d\u708e\u7684\u7b2c\u4e8c\u671f\u8a66\u9a57\u4e2d\u6e2c\u8a66\u8a72\u85e5\u7269\u7684\u6d3b\u6027\u6210\u5206\u3002\u8a72\u85e5\u5177\u6709\u96d9\u91cd\u4f5c\u7528\u6a5f\u5236\uff0c\u5b83\u57fa\u65bc\u7684\u662fGLP-1\u548cGIP\uff08\u80c3\u6291\u5236\u591a\u80bd\uff09\u9019\u5169\u7a2e\u6fc0\u7d20\u3002\u79ae\u4f86\u76ee\u524d\u5df2\u8655\u65bc\u7b2c\u4e8c\u671f\u7684\u81e8\u5e8a\u968e\u6bb5\uff0c\u9810\u8a082024\u5e74\u4e0a\u534a\u5e74\u5b8c\u6210\u4e3b\u8981\u7814\u7a76\u3002<\/p>\n\n\n\n<p>Mounjaro\u7684\u7b2c\u4e8c\u671f\u8a66\u9a57\u7d50\u679c\u986f\u793a\uff0c0.4mg\u7684\u5291\u91cf\u809d\u7e96\u7dad\u4e0d\u518d\u60e1\u5316\u7684\u6bd4\u4f8b\u6700\u9ad8\u53ef\u4ee5\u9054\u523059%\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E9%9D%9E%E6%B8%9B%E9%87%8D%E8%97%A5%E6%96%B0%E9%81%A9%E6%87%89%E7%97%87%E5%BB%A0%E5%95%86\"><\/span>\u975e\u6e1b\u91cd\u85e5\u65b0\u9069\u61c9\u75c7\u5ee0\u5546<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Akero%E7%9A%84Efruxifermin\"><\/span>Akero\u7684Efruxifermin<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>FGF21\u985e\u4f3c\u7269\u2f45\u2faf\uff0cAkero\uff08\u7f8e\u80a1\u4ee3\u78bc\uff1aAKRO\uff09\u958b\u767c\u7684Efruxifermin\u9032\u5ea6\u9818\u5148\uff0c\u5df2\u65bc2023\u5e7412\u2f49\u7387\u5148\u555f\u52d5\u7b2c\u4e09\u671f\u8a66\u9a57\uff0c\u9810\u8a082026\u5e744\u2f49\u53ef\u5b8c\u6210\u3002\u6839\u64daIIb\u671f\u7814\u7a76\u986f\u2f70\uff0cEfruxifermin\u7684\u5169\u500b\u5291\u91cf\u7d44\u85e5\u7269\u5747\u9054\u5230\u4e86\u6539\u5584\u809d\u81df\u7e96\u7dad\u5316\u7684\u4e3b\u8981\u7d42\u9ede\u548c\u591a\u500b\u6b21\u8981\u7d42\u9ede\uff0c\u4e14\u809d\u7a7f\u523a\u6578\u64da\u4eae\u773c\u3002\u8a66\u9a57\u7d50\u679c\u986f\u793a\uff0c28mg\u7684\u5291\u91cf\u809d\u7e96\u7dad\u4e0d\u518d\u60e1\u5316\u7684\u6bd4\u4f8b\u6700\u9ad8\u53ef\u4ee5\u9054\u523063%\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Inventiva%E7%9A%84Lanifibranor\"><\/span>Inventiva\u7684Lanifibranor<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Inventiva\u7684\uff08\u7f8e\u80a1\u4ee3\u78bc\uff1aIVA\uff09\u7684Lanifibranor\u662f\u2f00\u7a2e\u2f1d\u670d\u7684PPAR\u6fc0\u52d5\u5291\uff0c\u5728\u8a66\u9a57\u7d50\u679c\u986f\u793a\uff0c1.2mg\u7684\u5291\u91cf\u809d\u7e96\u7dad\u4e0d\u518d\u60e1\u5316\u7684\u6bd4\u4f8b\u6700\u9ad8\u53ef\u4ee5\u9054\u523049%\u3002\u4e09\u671f\u7814\u7a76\u9810\u8a082025\u5e749\u2f49\u5b8c\u6210\uff0c\u5982\u679c\u9806\u5229\u53d6\u5f97\u7a4d\u6975\u7684\u81e8\u5e8a\u6578\u64da\uff0c\u6216\u5c07\u65bc2026\u5e74\u4e0a\u534a\u5e74\u5411FDA\u7533\u8acb\u52a0\u901f\u6279\u51c6\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Sagimet%E7%9A%84Denifanstat\"><\/span>Sagimet\u7684Denifanstat<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>2024\u5e741\u2f4922\u2f47\uff0cSagimet\uff08\u7f8e\u80a1\u4ee3\u78bc\uff1aSGMT\uff09\u5ba3\u5e03Denifanstat\u6cbb\u7642MASH\u7684IIb\u671f\u7814\u7a76\u53d6\u5f97\u6b63\u2faf\u7d50\u679c\uff0c\u80a1\u50f9\u66b4\u6f32170%\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Madrigal%E7%9A%84Resmetirom\"><\/span>Madrigal\u7684Resmetirom<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<h5 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B8%82%E5%A0%B4%E7%9A%84%E9%A0%98%E5%85%88%E8%80%85\"><\/span>\u5e02\u5834\u7684\u9818\u5148\u8005<span class=\"ez-toc-section-end\"><\/span><\/h5>\n\n\n\n<p>\u99ac\u5fb7\u91cc\u52a0\u723e\uff08Madrigal\uff0c\u7f8e\u80a1\u4ee3\u78bc\uff1aMDGL\uff09\u958b\u767c\u7684Resmetirom\u662f\u4e00\u7a2eTHR-\u03b2\u6291\u5236\u5291\u30022022\u5e7412\u6708\uff0cMadrigal\u5ba3\u5e03\u65d7\u4e0b\u7684Resmetirom\u6cbb\u7642MASH\u7684\u4e09\u671f\u8a66\u9a57\u6210\u529f\u3002<\/p>\n\n\n\n<p>\u6839\u64da\u4e09\u671f\u8a66\u9a57\u7d50\u679c\u986f\u2f70\u8207\u5b89\u6170\u5291\u7d44\u76f8\u6bd4\uff0c\u5728\u63a5\u53d780mg\u548c100mg\u7684Resmetirom\u6cbb\u764252\u9031\u7684\u60a3\u8005\u4e2d\uff0c\u5206\u5225\u670926%\u548c30%\u7684\u60a3\u8005\u5be6\u73feMASH\u75c7\u72c0\u7de9\u89e3\u3002<\/p>\n\n\n\n<p>2022\u5e7412\u6708\uff0c\u53d7\u60e0\u65bcResmetirom\u81e8\u5e8a\u6578\u64da\u516c\u4f48\u7684\u6b21\u65e5\uff0c\u99ac\u5fb7\u91cc\u52a0\u723e\u7684\u80a1\u50f9\u66b4\u6f32268%\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E5%B7%B2%E8%A2%AB%E6%A0%B8%E6%B7%AE\"><\/span>\u5df2\u88ab\u6838\u6dee<span class=\"ez-toc-section-end\"><\/span><\/h5>\n\n\n\n<p>\u7f8e\u570b\u98df\u54c1\u85e5\u7269\u7ba1\u7406\u5c40 (FDA) \u5df2\u57282024\u5e743\u2f4914\u2f47\u6279\u51c6\u99ac\u5fb7\u91cc\u52a0\u723e\u7684resmetirom\u4f5c\u70ba\u7f8e\u570b\u6279\u51c6\u7684\u7b2c\u4e00\u500b\u6cbb\u7642\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e (NASH) \u809d\u81df\u75be\u75c5\u7684\u85e5\u7269\uff0c\u5b83\u7684\u6279\u51c6\u6a19\u8a8c\u8457\u91ab\u5b78\u53f2\u4e0a\u7684\u4e00\u500b\u91cc\u7a0b\u7891\u5f0f\u7684\u6c7a\u5b9a\u3002<\/p>\n\n\n\n<p>\u9019\u6b3e\u6bcf\u65e5\u4e00\u6b21\u7684\u53e3\u670d\u7532\u72c0\u817a\u6fc0\u7d20\u53d7\u9ad4 (THR) \u6fc0\u52d5\u5291\u7684\u7642\u6cd5\uff0c\u54c1\u724c\u7684\u540d\u7a31\u70ba Rezdiffra\uff0c\u5c07\u4ee54.7\u842c\u7f8e\u5143\u7684\u6a19\u50f9\u5728\u7f8e\u570b\u4e0a\u5e02\u3002\u6839\u64da FDA \u7684\u6a19\u7c64\u8a0a\u606f\uff0c\u9019\u6b3e\u540d\u70ba REZDIFFRA \u7684\u85e5\u7269\u5c07\u9069\u7528\u65bc\u60a3\u6709MASH\u548c\u4e2d\u5ea6\u81f3\u665a\u671f\u809d\u7e96\u7dad\u5316\u7684\u6210\u4eba\u60a3\u8005\u3002<\/p>\n\n\n\n<p>\u96a8\u8457\u9019\u9805\u5229\u591a\u6d88\u606f\u7684\u516c\u4f48\uff0cMadrigal\u5728\u7d50\u679c\u5f8c\u80a1\u50f9\u7acb\u5373\u2f24\u5e45\u66b4\u6f32\u4e8624%\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Viking%E7%9A%84VK2809\"><\/span>Viking\u7684VK2809<span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>\u4ee5THR-\u03b2\u6fc0\u52d5\u5291\u70ba\u57fa\u790e\uff0cViking\uff08\u7f8e\u80a1\u4ee3\u78bc\uff1aVKTX\uff09\u65bc2023\u5e745\u2f49\u5ba3\u5e03VK2809\u6cbb\u7642MASH\u7684\u7b2c\u4e8c\u671fVoyage\u7814\u7a76\u9054\u5230\u4e3b\u8981\u7d42\u9ede\uff08\u8a55\u4f30\u7b2c12\u9031\u60a3\u8005\u809d\u81df\u8102\u80aa\u542b\u91cf\u7684\u8b8a\u5316\uff09\uff0dVK2809\u7d44\u809d\u81df\u8102\u80aa\u542b\u91cf\u2f84\u5c11\u964d\u4f4e30%\u7684\u60a3\u8005\u6bd4\u4f8b\u6700\u2fbc\u905484.9%\u3002\u9810\u8a082024\u5e74\u4e0a\u534a\u5e74\u53ef\u5ba3\u4f48\u809d\u7a7f\u524c\u7684\u6578\u64da\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"121\" height=\"118\" src=\"https:\/\/www.granitefirm.com\/blog\/wp-content\/uploads\/2024\/02\/NASH-1600x1200-1.jpg\" alt=\"MASH\" class=\"wp-image-45635\"\/><figcaption class=\"wp-element-caption\">credit: thelivertransplant.com<\/figcaption><\/figure>\n\n\n\n<p><em><strong>\u672c\u4eba\u70ba\u539f\u6587\u4f5c\u8005\uff0c\u672c\u6587\u7cbe\u83ef\u7248\u539f\u520a\u767b\u5728Smart\u667a\u5bcc\u6708\u520b2024\u5e745\u6708\u865f<\/strong><\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"%E7%9B%B8%E9%97%9C%E6%96%87%E7%AB%A0\"><\/span>\u76f8\u95dc\u6587\u7ae0<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2025\/11\/06\/%e7%be%8e%e5%9c%8b%e6%9c%80%e5%a4%a7%e7%9a%84%e9%86%ab%e7%99%82%e9%99%a2%e6%89%80hca-healthcare\/\">\u7f8e\u570b\u6700\u5927\u7684\u91ab\u7642\u9662\u6240HCA Healthcare\u5982\u4f55\u8cfa\u9322\uff1f<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2025\/10\/18\/%e4%b8%ad%e5%9c%8b%e7%9a%84%e7%94%9f%e6%8a%80%e8%a3%bd%e8%97%a5%e6%a5%ad%e9%96%8b%e5%a7%8b%e5%b1%95%e7%8f%be%e5%ae%83%e7%9a%84%e6%b7%b1%e5%ba%a6%e6%b1%82%e7%b4%a2%e6%99%82%e5%88%bb\/\">\u4e2d\u570b\u7684\u751f\u6280\u88fd\u85e5\u696d\u958b\u59cb\u5c55\u73fe\u5b83\u7684\u6df1\u5ea6\u6c42\u7d22\u6642\u523b<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2025\/09\/16\/%e5%ba%b7%e6%96%b9%e8%82%ba%e7%99%8c%e8%97%a5%e6%96%b0%e8%97%a5%e7%99%82%e6%95%88%e5%a4%a7%e5%8b%9d%e5%85%a8%e7%90%83%e8%97%a5%e6%a6%9c%e9%8a%b7%e9%87%8f%e5%86%a0%e8%bb%8d\/\">\u5eb7\u65b9\uff08Akeso&nbsp;\uff09\u80ba\u764c\u85e5\u65b0\u85e5\u7642\u6548\u5927\u52dd\u5168\u7403\u85e5\u699c\u92b7\u91cf\u51a0\u8ecd\uff0c\u9707\u64bc\u7684\u751f\u6280\u696dDeepSeek\u4e8b\u4ef6<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/11\/02\/%e5%9f%ba%e5%9b%a0%e7%b7%a8%e8%bc%afcasgevy%e8%a2%ab%e6%89%b9%e5%87%86\/\">\u5168\u7403\u9996\u500b\u57fa\u56e0\u7de8\u8f2f\u7642\u6cd5Casgevy\u7d42\u65bc\u88ab\u6279\u51c6\u4e0a\u5e02<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/11\/17\/%E5%9F%BA%E5%9B%A0%E7%B7%A8%E8%BC%AF%E7%99%82%E6%B3%95%E5%89%B5%E5%A7%8B%E8%80%85crispr%E5%A6%82%E4%BD%95%E8%B3%BA%E9%8C%A2%EF%BC%9F\/\">\u57fa\u56e0\u7de8\u8f2f\u7642\u6cd5\u5275\u59cb\u8005CRISPR\u5982\u4f55\u8cfa\u9322\uff1f<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/02\/%E9%9D%9E%E9%85%92%E7%B2%BE%E6%80%A7%E8%84%82%E8%82%AA%E8%82%9D%E7%82%8Emash\/#google_vignette\" target=\"_blank\" rel=\"noreferrer noopener\">FDA\u9996\u6b21\u6279\u51c6\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u708e(MASH)\u6cbb\u7642\u85e5\u7269<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/28\/%e6%8a%97%e7%97%85%e6%af%92%e8%97%a5%e7%8e%8b%e5%90%89%e5%88%a9%e5%be%b7%e9%96%8b%e7%99%bc%e5%87%ba%e4%b8%96%e4%b8%8a%e9%a6%96%e6%94%af%e6%84%9b%e6%bb%8b%e7%96%ab%e8%8b%97\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u6297\u75c5\u6bd2\u85e5\u738b\u5409\u5229\u5fb7\uff08Gilead\uff09\u958b\u767c\u51fa\u4e16\u4e0a\u9996\u652f\u611b\u6ecb\u75ab\u82d7<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2024\/06\/06\/%e5%90%8c%e6%99%82%e6%8f%a1%e6%9c%89%e5%85%a9%e5%a4%a7%e6%9c%aa%e4%be%86%e6%98%8e%e6%98%9f%e6%96%b0%e8%97%a5%e7%9a%84%e7%b6%ad%e4%ba%acviking\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u540c\u6642\u63e1\u6709\u5169\u5927\u672a\u4f86\u660e\u661f\u65b0\u85e5\u7684\u7dad\u4eac\uff08Viking\uff09<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/11\/15\/%e7%a6%ae%e4%be%86%e7%82%ba%e4%bd%95%e8%83%bd%e6%88%90%e7%82%ba%e6%96%b0%e4%b8%80%e4%bb%a3%e7%9a%84%e5%85%a8%e7%90%83%e8%a3%bd%e8%97%a5%e5%b8%82%e5%80%bc%e7%8e%8b%ef%bc%9f\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u79ae\u4f86\uff08Eli Lilly\uff09\u70ba\u4f55\u80fd\u6210\u70ba\u65b0\u4e00\u4ee3\u7684\u5168\u7403\u88fd\u85e5\u5e02\u503c\u738b\uff1f<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/12\/07\/%E9%98%BF%E8%8C%B2%E6%B5%B7%E9%BB%98%E7%97%87%EF%BC%8C%E5%94%AF%E4%B8%80%E5%B0%9A%E5%BE%85%E6%94%BB%E5%85%8B%E7%9A%84%E4%B8%BB%E8%A6%81%E7%96%BE%E7%97%85%E7%9A%84%E7%9B%AE%E5%89%8D%E9%80%B2%E5%B1%95\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u963f\u8332\u6d77\u9ed8\u75c7\uff0c\u552f\u4e00\u5c1a\u5f85\u653b\u514b\u7684\u4e3b\u8981\u75be\u75c5\u7684\u76ee\u524d\u9032\u5c55\u548c\u76f8\u95dc\u4f01\u696d<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/03\/30\/%e8%ab%be%e5%92%8c%e8%ab%be%e5%be%b7%e5%8f%b8%e7%be%8e%e6%a0%bc%e9%ad%af%e8%82%bd%e5%92%8c%e8%85%b8%e6%b3%8c%e7%b4%a0%e7%9a%84%e6%b8%9b%e9%87%8d%e6%95%88%e6%9e%9c\/\">\u8afe\u548c\u8afe\u5fb7\uff08Novo Nordisk\uff09\u7cd6\u5c3f\u75c5\u7684\u65b0\u85e5Semaglutide\uff08\u53f8\u7f8e\u683c\u9b6f\u80bd\uff09\u8afe\u548c\u6cf0 Ozempic\uff0cWegovy\u548cMounjaro\u88ab\u767c\u73fe\u5177\u6709\u9a5a\u4eba\u7684\u6e1b\u91cd\u6548\u679c<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/08\/09\/%e4%bc%b0%e5%80%bc%e9%a9%9a%e4%ba%ba%e7%9a%84%e5%a4%a7%e8%97%a5%e5%bb%a0%e7%a6%ae%e4%be%86\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u6700\u65b0\u5e02\u503c\u5168\u7403\u7b2c\u4e00\u4f30\u503c\u9a5a\u4eba\u7684\u5927\u85e5\u5ee0\u79ae\u4f86\uff08Eli Lilly\uff09<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/08\/07\/%e6%b8%9b%e9%87%8d%e8%97%8d%e6%b5%b7%e6%98%af%e8%97%a5%e5%93%81%e5%b8%82%e5%a0%b4%e6%9c%aa%e4%be%86%e7%9a%84%e9%87%91%e9%9b%9e%e6%af%8d\/\">\u6e1b\u91cd\u85cd\u6d77\u662f\u85e5\u54c1\u5e02\u5834\u672a\u4f86\u7684\u91d1\u96de\u6bcd<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/01\/16\/%e6%88%90%e5%8a%9f%e7%9a%84%e4%bc%81%e6%a5%ad%e4%b8%8d%e6%98%af%e6%8a%80%e8%a1%93%e7%99%bc%e6%98%8e%e8%80%85\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u6280\u8853\u767c\u660e\u8005\u5f88\u5c11\u6210\u529f\uff0c\u6539\u826f\u5275\u65b0\u8005\u53cd\u800c\u6210\u529f\u7372\u5229<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/11\/06\/%E6%9B%BE%E7%B6%93%E7%9A%84%E5%85%A8%E7%90%83%E5%A4%A7%E8%97%A5%E5%BB%A0%E9%BB%98%E6%B2%99%E6%9D%B1%EF%BC%88Merck%EF%BC%89\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u66fe\u7d93\u7684\u5168\u7403\u5927\u85e5\u5ee0\u9ed8\u6c99\u6771\uff08Merck\uff09<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/03\/30\/%e8%ab%be%e5%92%8c%e8%ab%be%e5%be%b7%e5%8f%b8%e7%be%8e%e6%a0%bc%e9%ad%af%e8%82%bd%e5%92%8c%e8%85%b8%e6%b3%8c%e7%b4%a0%e7%9a%84%e6%b8%9b%e9%87%8d%e6%95%88%e6%9e%9c\/\">\u8afe\u548c\u8afe\u5fb7\uff08Novo Nordisk\uff09\u7cd6\u5c3f\u75c5\u7684\u65b0\u85e5Semaglutide\uff08\u53f8\u7f8e\u683c\u9b6f\u80bd\uff09\u8afe\u548c\u6cf0 Ozempic\uff0cWegovy\u548cMounjaro\u88ab\u767c\u73fe\u5177\u6709\u9a5a\u4eba\u7684\u6e1b\u91cd\u6548\u679c<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2022\/07\/02\/%E5%85%A8%E7%90%83%E6%9C%80%E9%87%8D%E8%A6%81%E7%9A%84%E9%86%AB%E7%99%82%E5%99%A8%E6%9D%90%E5%92%8C%E7%87%9F%E9%A4%8A%E9%A3%9F%E5%93%81%E5%95%86%E4%BA%9E%E5%9F%B9\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u5168\u7403\u6700\u91cd\u8981\u7684\u91ab\u7642\u5668\u6750\u548c\u71df\u990a\u98df\u54c1\u5546\u4e9e\u57f9\uff08Abbott\uff09\u662f\u5982\u4f55\u8cfa\u9322\u7684\uff1f<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2022\/06\/24\/%e9%bb%98%e5%85%8b\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u7a4f\u5b9a\u7684\u9053\u74ca\u88fd\u85e5\u6210\u4efd\u80a1\u9ed8\u6c99\u6771\uff08Merck\uff09\u5982\u4f55\u8cfa\u9322\uff1f<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2022\/11\/29\/%e7%be%8e%e8%82%a1%e4%b8%bb%e8%a6%81%e8%97%a5%e5%bb%a0%e5%88%86%e6%8b%86%e5%8f%b2\/\">\u7f8e\u80a1\u4e3b\u8981\u85e5\u5ee0\u5206\u62c6\u53f2\uff0c\u548c\u6301\u6709\u5176\u80a1\u7968\u7684\u597d\u8655<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2022\/11\/18\/%e8%99%95%e6%96%b9%e8%97%a5%e9%a0%98%e5%b0%8e%e5%95%86%e8%89%be%e4%bc%af%e7%b6%ad\/\">\u4e0b\u4e00\u500b\u6392\u540d\u7b2c\u4e00\u7684\u88fd\u85e5\u696d\u9818\u8896\u827e\u4f2f\u7dad\uff08AbbVie\uff09<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2023\/05\/17\/%e7%be%85%e6%b0%8f%e6%8a%97%e7%99%8c%e8%97%a5%e7%a5%9e\/\">\u7f85\u6c0f\u88fd\u85e5\uff08Roche\uff09\uff0c\u6297\u764c\u85e5\u795e<\/a>\u300b<\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/?s=%E5%85%A8%E7%90%83%E7%AC%AC%E4%B8%80%E5%A4%A7%E8%97%A5%E5%BB%A0%E8%BC%9D\" target=\"_blank\" rel=\"noreferrer noopener\">\u5168\u7403\u7b2c\u4e00\u5927\u85e5\u5ee0\u8f1d\u745e\uff08Pfizer<\/a>\uff09\u300b<\/li>\n\n\n\n<li><span style=\"font-size: revert;\">\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/blog\/2022\/09\/21\/%e5%ac%8c%e7%94%9fj%e6%98%af%e5%a6%82%e4%bd%95%e8%b3%ba%e9%8c%a2%e7%9a%84\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u64c1\u67093A\u50b5\u4fe1\u8a55\u7b49\u7684\u5b0c\u751f\uff08Johnson &amp; Johnson\uff09\u662f\u5982\u4f55\u8cfa\u9322\u7684\uff1f<\/a>\u300b<\/span><\/li>\n\n\n\n<li>\u300a<a href=\"https:\/\/www.granitefirm.com\/blog\/?s=%E5%85%A8%E7%90%83%E7%AC%AC%E4%B8%80%E5%A4%A7%E8%97%A5%E5%BB%A0%E8%BC%9D\" target=\"_blank\" rel=\"noreferrer noopener\">\u5168\u7403\u7b2c\u4e00\u5927\u85e5\u5ee0\u8f1d\u745e\uff08Pfizer<\/a>\uff09\u300b<\/li>\n<\/ul>\n\n\n\n<p><em><strong>\u91cd\u8981\u8072\u660e<\/strong><\/em><\/p>\n\n\n\n<ul 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